Evidence map›Paper›PMID 36721101›Full record

ArticleBMC neurology2023

The association between liver fibrosis and depression in patients after ischemic stroke.

Yun Zhang, Yao Yang, Yue Feng, Zhonglun Chen, Lin He, Shu Xie, Jian Shi, Bufan Yang, Yufeng Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yun ZhangDepartment of Psychosomatic Medicine, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, 12 Changjia Alley, Mianyang, 621000, Sichuan, China. zhangyun_neuro@126.com.
Yao YangDepartment of Psychosomatic Medicine, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, 12 Changjia Alley, Mianyang, 621000, Sichuan, China.
Yue FengDepartment of Clinical Laboratory, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, Sichuan, China.
Zhonglun ChenDepartment of Neurology, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, 12 Changjia Alley, Mianyang, 621000, Sichuan, China.
Lin HeDepartment of Psychosomatic Medicine, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, 12 Changjia Alley, Mianyang, 621000, Sichuan, China.
Shu XieDepartment of Psychosomatic Medicine, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, 12 Changjia Alley, Mianyang, 621000, Sichuan, China.
Jian ShiDepartment of Psychosomatic Medicine, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, 12 Changjia Alley, Mianyang, 621000, Sichuan, China.
Bufan YangDepartment of Neurology, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, 12 Changjia Alley, Mianyang, 621000, Sichuan, China.
Yufeng TangDepartment of Neurology, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, 12 Changjia Alley, Mianyang, 621000, Sichuan, China. dryufeng@126.com.
University of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveLiver fibrosis has been considered a predictor of cardiovascular disease. This study aimed to evaluate whether the degree of liver fibrosis is related to post-stroke depression (PSD) at 3 months follow-up.

methodsWe prospectively and continuously enrolled patients with first-ever ischemic stroke from June 2020 to January 2022. Liver fibrosis was measured after admission by calculating the Fibrosis-4 index (FIB-4) and stratified into two categories (< 2.67 versus ≥ 2.67). Patients with a 17-item Hamilton Depression Scale score > 7 were further evaluated using the Chinese version of the structured clinical interview of DSM-IV, for diagnosing PSD at 3 months.

resultsA total of 326 patients (mean age 66.6 years, 51.5% male) were recruited for the study. As determined by the FIB-4 score, 80 (24.5%) patients had advanced liver fibrosis. During the follow-up, PSD was observed in 91 patients, which accounted for 27.9% (95% confidence interval [CI] 25.5%-30.5%) of the cohort. The prevalence of advanced liver fibrosis was higher in PSD patients than those without PSD (40.0% versus 24.0%; P = 0.006). After adjustment for covariates in the multivariate logistic analysis, advanced fibrosis was significantly associated with PSD (odds ratio [OR], 1.88; 95% CI, 1.03-3.42; P = 0.040). Similar results were found when the FIB-4 was analyzed as a continuous variable.

conclusionsThis study found that advanced liver fibrosis was associated with an increased risk of 3-month PSD. FIB-4 score may be valuable for screening depressive symptoms in ischemic stroke patients.

Indexed as

DepressionIschemic StrokeLiver CirrhosisAgedFemaleHumansMaleDepressive symptomsFibrosis-4 indexIschemic strokeLiver fibrosisRisk factor

Identifiers

PMID36721101
PMCPMC9887868
OpenAlexW4318616197

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.