Evidence map›Paper›PMID 36721083›Full record

Observational studyBMC anesthesiology2023

Ratio of carbon dioxide veno-arterial difference to oxygen arterial-venous difference is not associated with lactate decrease after fluid bolus in critically ill patients with hyperlactatemia: results from a prospective observational study.

Keitiane Kaefer, Charalampos Pierrakos, Thomas Nguyen, Dimitrios Velissaris, Rachid Attou, Jacques Devriendt, Sabino Scolletta, Fabio Silvio Taccone

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Keitiane KaeferIntensive Care Department, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Charalampos PierrakosIntensive Care Department, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium. charalampos_p@hotmail.com.
Thomas NguyenIntensive Care Department, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Dimitrios VelissarisInternal Medicine Department, University Hospital of Patras, Patras, Greece.
Rachid AttouIntensive Care Department, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Jacques DevriendtIntensive Care Department, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Sabino ScollettaDepartment of Emergency-Urgency and Organ Transplantation, Anesthesia and Intensive Care, University Hospital of Siena, Siena, Italy.
Fabio Silvio TacconeIntensive Care Department, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh ratio of the carbon dioxide veno-arterial difference to the oxygen arterial-venous difference (P

methodsThis prospective observational study examined adult patients in the intensive care unit (ICU) with lactate levels > 1.5 mmol/L who received FBs. Blood-lactate levels were measured before and after FB under unchanged metabolic, respiratory, and hemodynamic conditions. The primary outcome was blood-lactate levels after FB. Significant decreases in blood-lactate levels were considered as blood-lactate levels < 1.5 mmol/L or a decrease of more than 10% compared to baseline.

resultsThe study enrolled 40 critically ill patients, and their median concentration of blood lactate was 2.6 [IQR:1.9 - 3.8] mmol/L. There were 27 (68%) patients with P

conclusionsIn critically ill patients with hyperlactatemia, P

Indexed as

HyperlactatemiaLactic AcidAdultCarbon DioxideCritical IllnessHumansOxygenCarbon DioxideLactic AcidOxygenFluid challengeFluid expansionLactate clearanceOxygen consumptionPCO2 gapTissue hypoxiaTissue perfusionVeno-arterial carbon dioxide gapVenous oxygen saturation

Identifiers

PMID36721083
PMCPMC9887917

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.