ArticleThe ISME journal2023
Unexpected complexity of the ammonia monooxygenase in archaea.
Article in The ISME journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Oxygen production as an electron overflow pathway in ammonia-oxidizing archaea.Science advances · 2026Article
- Ammonia monooxygenase: a work in progress.Chemical science · 2026Review
- Copper requirements and copper toxicity as niche-defining factors in the growth of terrestrial ammonia-oxidizing archaea and bacteria.FEMS microbiology ecology · 2026Article
- Taxonomy and functional profile of microbial communities across the depths of the Alpine Cenote Abyss ice cave.Scientific reports · 2025Article
- Structural insights into the catalytic mechanism of ammonia monooxygenase.Nature communications · 2025Article
- Urea use drives niche separation between dominant marine ammonia oxidizing archaea.Nature communications · 2025Article
- Targeted assembly recovers high ammonia monooxygenase diversity in mudflat intertides.mSystems · 2025Article
- Novel hot spring Thermoproteota support vertical inheritance of ammonia oxidation and carbon fixation in Nitrososphaeria.Access microbiology · 2025Article
- Article
- Metagenome-assembled genomes of two nitrifying microorganisms from the freshwater archaeal ammonia-oxidizing enrichment culture BO1.Microbiology resource announcements · 2024Article
- Direct Methane Oxidation by Copper- and Iron-Dependent Methane Monooxygenases.Chemical reviews · 2024Review
- Novel order-level lineage of ammonia-oxidizing archaea widespread in marine and terrestrial environments.The ISME journal · 2024Article
- Metabolic potential of Nitrososphaera-associated clades.The ISME journal · 2024Article
- Dynamics and activity of an ammonia-oxidizing archaea bloom in South San Francisco Bay.The ISME journal · 2024Article
- Activity of novel virus families infecting soil nitrifiers is concomitant with host niche differentiation.The ISME journal · 2024Article
- Activity-based labelling of ammonia- and alkane-oxidizing microorganisms including ammonia-oxidizing archaea.ISME communications · 2024Article
- Ultrastructural insights into cellular organization, energy storage and ribosomal dynamics of an ammonia-oxidizing archaeon from oligotrophic oceans.Frontiers in microbiology · 2024Article
- Growth of soil ammonia-oxidizing archaea on air-exposed solid surface.ISME communications · 2024Article
- Assessing the activity of different plant-derived molecules and potential biological nitrification inhibitors on a range of soil ammonia- and nitrite-oxidizing strains.Applied and environmental microbiology · 2023Article
- Transcriptomic Insights into Archaeal Nitrification in the Amundsen Sea Polynya, Antarctica.Journal of microbiology (Seoul, Korea) · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ammonia oxidation, as the first step of nitrification, constitutes a critical process in the global nitrogen cycle. However, fundamental knowledge of its key enzyme, the copper-dependent ammonia monooxygenase, is lacking, in particular for the environmentally abundant ammonia-oxidizing archaea (AOA). Here the structure of the enzyme is investigated by blue-native gel electrophoresis and proteomics from native membrane complexes of two AOA. Besides the known AmoABC subunits and the earlier predicted AmoX, two new protein subunits, AmoY and AmoZ, were identified. They are unique to AOA, highly conserved and co-regulated, and their genes are linked to other AMO subunit genes in streamlined AOA genomes. Modeling and in-gel cross-link approaches support an overall protomer structure similar to the distantly related bacterial particulate methane monooxygenase but also reveals clear differences in extracellular domains of the enzyme. These data open avenues for further structure-function studies of this ecologically important nitrification complex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.