ArticleNature communications2023
A supramolecular cucurbit[8]uril-based rotaxane chemosensor for the optical tryptophan detection in human serum and urine.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 62 citations in OpenAlex.
- Nanomolar Affinity Host-Dye Reporter Pairs from Fluorescently Labeled Oligoarginine Peptides and p-Sulfonatocalix[4]arene.Chembiochem : a European journal of chemical biology · 2026Article
- The Rise and Promise of Macrocyclic Hosts in Biomedicine.ACS central science · 2025Review
- Inclusion Complexation of Oxymetazoline Hydrochloride and Xylometazoline Hydrochloride with Cucurbit[n]urils (ACS omega · 2025Article
- Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems.Angewandte Chemie (International ed. in English) · 2025Review
- Interlocking Pseudorotaxanes through Borane- and Boronic Ester-Mediated Carbon-Carbon Bond Formation.Organic letters · 2025Article
- Glucose-derived receptors for photo-controlled binding of amino acid esters in water.Communications chemistry · 2025Article
- Multimodal Molecular Motion in the Rotaxanes and Catenanes Incorporating Flexible Calix[n]phyrin Stations.Angewandte Chemie (International ed. in English) · 2025Article
- Binding of tryptophan and tryptophan-containing peptides in water by a glucose naphtho crown ether.Beilstein journal of organic chemistry · 2025Article
- 'Rewritable' and 'liquid-specific' recognizable wettability pattern.Nature communications · 2024Article
- Curved Nanographenes as Stoppers in a [2]Rotaxane with Two-Photon Excited Emission.The Journal of organic chemistry · 2024Article
- Cucurbit[8]uril-based supramolecular theranostics.Journal of nanobiotechnology · 2024Review
- Transitioning from Supramolecular Chemistry to Molecularly Imprinted Polymers in Chemical Sensing.Sensors (Basel, Switzerland) · 2023Article
- A supramolecular cucurbit[8]uril-based rotaxane chemosensor for the optical tryptophan detection in human serum and urine.Nature communications · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensing small biomolecules in biofluids remains challenging for many optical chemosensors based on supramolecular host-guest interactions due to adverse interplays with salts, proteins, and other biofluid components. Instead of following the established strategy of developing alternative synthetic binders with improved affinities and selectivity, we report a molecular engineering approach that addresses this biofluid challenge. Here we introduce a cucurbit[8]uril-based rotaxane chemosensor feasible for sensing the health-relevant biomarker tryptophan at physiologically relevant concentrations, even in protein- and lipid-containing human blood serum and urine. Moreover, this chemosensor enables emission-based high-throughput screening in a microwell plate format and can be used for label-free enzymatic reaction monitoring and chirality sensing. Printed sensor chips with surface-immobilized rotaxane-microarrays are used for fluorescence microscopy imaging of tryptophan. Our system overcomes the limitations of current supramolecular host-guest chemosensors and will foster future applications of supramolecular sensors for molecular diagnostics.
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