ArticleTranslational psychiatry2023
White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging.
Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Trial
- The role of dopamine decline, astrocyte reactivity and cerebral small-vessel disease in cognitive aging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- 10-year longitudinal dopamine D2-receptor losses are associated with cognitive decline in healthy aging.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Associations between inflammation and striatal dopamine D2-receptor availability in aging.Journal of neuroinflammation · 2025Article
- Working Memory Training Responsiveness in Parkinson's Disease Is Not Determined by Cortical Thickness or White Matter Lesions.Journal of Parkinson's disease · 2024Article
- Cerebrovascular integrity affects gradients of aging-related dopamine D1 differences in the striatum.Aging brain · 2023Article
- Five-year associations among dopamine D2-like receptor loss, cognitive decline, education, and self-reported leisure activities in healthy older adults.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
5 authors.
Funding
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Abstract
Age-related dopamine reductions have been suggested to contribute to maladaptive working memory (WM) function in older ages. One promising intervention approach is to increase physical activity, as this has been associated with plasticity of the striatal dopamine system and WM improvements, however with individual differences in efficacy. The present work focused on the impact of individual differences in white-matter lesion burden upon dopamine D2-like receptor (DRD2) availability and WM changes in response to a 6 months physical activity intervention. While the intervention altered striatal DRD2 availability and WM performance in individuals with no or only mild lesions (p < 0.05), no such effects were found in individuals with moderate-to-severe lesion severity (p > 0.05). Follow-up analyses revealed a similar pattern for processing speed, but not for episodic memory performance. Linear analyses further revealed that lesion volume (ml) at baseline was associated with reduced DRD2 availability (r = -0.41, p < 0.05), and level of DRD2 change (r = 0.40, p < 0.05). Taken together, this study underlines the necessity to consider cerebrovascular health in interventions with neurocognitive targets. Future work should assess whether these findings extend beyond measures of DRD2 availability and WM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.