Evidence map›Paper›PMID 36720837›Full record

ReviewNeurocritical care2023

Neuromonitoring During ECMO Support in Children.

Ryan J Felling, Asavari Kamerkar, Matthew L Friedman, Ahmed S Said, Kerri L LaRovere, Michael J Bell, Melania M Bembea

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurocritical care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Observational
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  4. Observational
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  6. Article
  7. Death by Neurologic Criteria in Neonates Undergoing Extracorporeal Membrane Oxygenation: Extracorporeal Life Support Organization Registry Study, 2010-2023.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026
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  10. Review
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  12. Review
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  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Ryan J FellingDepartment of Neurology, Johns Hopkins University School of Medicine, 200 N. Wolfe Street, Suite 2158, Baltimore, MD, USA. rfelling@jhmi.edu.ORCID 0000-0002-0845-9356
Asavari KamerkarDepartment of Anesthesia Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Matthew L FriedmanDivision of Pediatric Critical Care, Indiana School of Medicine, Indianapolis, IN, USA.
Ahmed S SaidDivision of Pediatric Critical Care, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Kerri L LaRovereDepartment of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Michael J BellDivision of Critical Care Medicine, Department of Pediatrics, Children's National Medical Center, Washington, DC, USA.
Melania M BembeaDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USBoston Children's Hospital · USChildren's Hospital of Los Angeles · USChildren's National · USIndiana University – Purdue University Indianapolis · USWashington University in St. Louis · US

Funding

Biomarkers of Brain Injury in Critically-Ill Children on Extracorporeal Membrane Oxygenation (ECMO)R01NS106292 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BEMBEA, MELANIA MARIA · 2019 to 2023
$3.1M
NINDS NIH HHS R01NS106292
6 · The paper itself

Abstract

Extracorporeal membrane oxygenation is a potentially lifesaving intervention for children with severe cardiac or respiratory failure. It is used with increasing frequency and in increasingly more complex and severe diseases. Neurological injuries are important causes of morbidity and mortality in children treated with extracorporeal membrane oxygenation and include ischemic stroke, intracranial hemorrhage, hypoxic-ischemic injury, and seizures. In this review, we discuss the epidemiology and pathophysiology of neurological injury in patients supported with extracorporeal membrane oxygenation, and we review the current state of knowledge for available modalities of monitoring neurological function in these children. These include structural imaging with computed tomography and ultrasound, cerebral blood flow monitoring with near-infrared spectroscopy and transcranial Doppler ultrasound, and physiological monitoring with electroencephalography and plasma biomarkers. We highlight areas of need and emerging advances that will improve our understanding of neurological injury related to extracorporeal membrane oxygenation and help to reduce the burden of neurological sequelae in these children.

Indexed as

Extracorporeal Membrane OxygenationChildHumansIntracranial HemorrhagesSeizuresUltrasonographyUltrasonography, Doppler, TranscranialBiomarkersElectroencephalographyExtracorporeal membrane oxygenationIntracranial hemorrhageNeuroimagingSeizuresStrokeTranscranial doppler

Identifiers

PMID36720837
OpenAlexW4318696212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.