Evidence map›Paper›PMID 36720468›Full record

ArticleMolecular and cellular biology2023

Transcriptional Regulation of

Yoko Yagishita, Tanvi Joshi, Thomas W Kensler, Nobunao Wakabayashi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yoko YagishitaTranslational Research Program, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Tanvi JoshiTranslational Research Program, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Thomas W KenslerTranslational Research Program, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-6676-261X
Nobunao WakabayashiTranslational Research Program, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0003-4643-7841
Fred Hutch Cancer Center · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Targeting Nrf2 for Cancer ChemopreventionR35CA197222 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KENSLER, THOMAS W · 2015 to 2021
$6.7M
NCI NIH HHS P30 CA015704NCI NIH HHS R35 CA197222
6 · The paper itself

Abstract

The physiological roles of aryl hydrocarbon receptor (AhR) in the small intestine have been revealed as immunomodulatory and barrier functions. However, its contributions to cell fate regulation are incompletely understood. The Notch-activated signaling cascade is a central component of intestinal cell fate determinations. The lateral inhibitory mechanism governed by Notch directs cell fates toward distinct cell lineages (i.e., absorptive and secretory cell lineages) through its downstream effector, mouse atonal homolog 1 (MATH1). An investigation employing cell lines and intestinal crypt cells revealed that AhR regulates

Indexed as

IntestinesReceptors, Aryl HydrocarbonAnimalsBasic Helix-Loop-Helix ProteinsGene Expression RegulationIntestine, SmallMiceStem CellsAtoh1 protein, mouseBasic Helix-Loop-Helix ProteinsReceptors, Aryl HydrocarbonAhRgoblet cellsintestinal organoidsMath1Math1+ progenitor cells

Identifiers

PMID36720468
PMCPMC9937019
OpenAlexW4318195439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.