ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Early axonal degeneration linked to clinical decline in Alzheimer's disease progression revealed with diffusion MRI.The Journal of clinical investigation · 2026Trial
- Effects of iron repletion on brain iron content, myelination, neural network activation, and cognition.JCI insight · 2025Trial
- Oligodendrocyte dysfunction in human age-related cognitive decline.Nature medicine · 2026Article
- Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026Review
- Review
- Nanofiber-based platform for quantitative analysis of human oligodendrocyte ensheathment with pharmacological perturbations.Stem cell reports · 2026Article
- Input Layer Regularization and Automated Regularization Hyperparameter Tuning for Myelin Water Estimation Using Deep Learning.NMR in biomedicine · 2026Article
- Multi-omics validation of myelin water fraction as a myelin-specific MRI biomarker.NeuroImage · 2026Article
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- Article
- Single-cell epigenomics uncovers heterochromatin instability and transcription factor dysfunction during mouse brain aging.Cell reports · 2026Article
- ACSS2 maintains oligodendrocyte progenitor cell pool and is required for myelination during development and aging.Nature aging · 2026Article
- Cerebellar Tissue Properties Alterations in Fibromyalgia: A T1w/T2w Ratio Study.Human brain mapping · 2026Article
- Excess iron in deep gray matter is associated with cognitive and functional decline: The mediating role of white matter myelin.NeuroImage · 2026Article
- Association of Oral Hypofunction with Reduced Hand Dexterity in Community-Dwelling Older Adults: A Cross-Sectional Study.Clinical interventions in aging · 2026Article
- Effect of Water Temperature during Aquatic Exercise on Cognitive Impairment in Mice with Chronic Cerebral Hypoperfusion.Journal of vascular research · 2026Article
- Age-related differences in choroid plexus structural integrity are associated with changes in cognition.Fluids and barriers of the CNS · 2025Article
- Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study.Brain, behavior, & immunity - health · 2025Article
- Central Obesity Disrupts Brain Network Organization in Aging via Metabolic and Structural Pathways.Aging and disease · 2025Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThe influence of myelination on longitudinal changes in cognitive performance remains unclear.
methodsFor each participant (N = 123), longitudinal cognitive scores were calculated. Myelin content was probed using myelin water fraction (MWF) or longitudinal relaxation rate (R
resultsLower MWF was associated with steeper declines in executive function (p < .02 in all regions) and lower R DISCUSSION: We demonstrate significant relationships between myelin content and the rates of change in cognitive performance among cognitively normal individuals. These findings highlight the importance of myelin in cognitive functioning and suggest MWF and R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.