Evidence map›Paper›PMID 36719987›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2023

Nephronectin is required to maintain right lung lobar separation during embryonic development.

Carole L Wilson, Chi F Hung, Brian M Burkel, Suzanne M Ponik, Sina A Gharib, Lynn M Schnapp

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Characterisation of a COPD-associated nephronectin (The European respiratory journal · 2025
    Article
  5. Article
  6. Integrin Alpha8 Beta1 (81): An In-Depth Review of an Overlooked RGD-Binding Receptor.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2025
    Article
  7. Genetics of chronic respiratory disease.Nature reviews. Genetics · 2024
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Carole L WilsonDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States.ORCID 0000-0001-6692-0430
Chi F HungDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, United States.ORCID 0000-0001-6408-0773
Brian M BurkelDepartment of Cell and Regenerative Biology, University of Wisconsin, Madison, Wisconsin, United States.
Suzanne M PonikDepartment of Cell and Regenerative Biology, University of Wisconsin, Madison, Wisconsin, United States.
Sina A GharibDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, United States.ORCID 0000-0002-2480-4367
Lynn M SchnappDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, University of Wisconsin, Madison, Wisconsin, United States.ORCID 0000-0002-9189-7567
University of Wisconsin–Madison · USUniversity of Washington · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Functional diversity of lung pericytes in lung injuryR01HL166273 · NHLBI · UNIVERSITY OF WASHINGTON · PI Chi F Hung · 2023 to 2026
$2.5M
Role of pericytes in scleroderma skin and lung fibrosisR01HL133751 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI FEGHALI-BOSTWICK, CAROL A., SCHNAPP, LYNN M · 2017 to 2020
$2.0M
Application of single-cell trajectory analysis in single-cell transcriptomics to elucidate the biology of lung pericytes in injury, repair, and regenerationR03HL155075 · NHLBI · UNIVERSITY OF WASHINGTON · PI HUNG, CHI F · 2022 to 2023
$177k
NCI NIH HHS P30 CA014520NHLBI NIH HHS R01 HL133751NHLBI NIH HHS R01 HL166273NHLBI NIH HHS R03 HL155075
6 · The paper itself

Abstract

Nephronectin (NPNT) is a basement membrane (BM) protein and high-affinity ligand of integrin α8β1 that is required for kidney morphogenesis in mice. In the lung, NPNT also localizes to BMs, but its potential role in pulmonary development has not been investigated. Mice with a floxed

Indexed as

Extracellular Matrix ProteinsMembrane ProteinsAnimalsCollagenEmbryonic DevelopmentLungMiceCollagenExtracellular Matrix ProteinsMembrane Proteinsnephronectinbasement membraneembryogenesismesotheliumvisceral pleura

Identifiers

PMID36719987
PMCPMC10027138
OpenAlexW4318696213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.