Evidence map›Paper›PMID 36719911›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Facile and dynamic cleavage of every iron-sulfide bond in cuboidal iron-sulfur clusters.

Niklas B Thompson, Gil Namkoong, Brighton A Skeel, Daniel L M Suess

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. A kinetic mathematical model of comprehensive iron metabolism in a respiring yeast cell: a basic-pathways approach to solving a large system dynamically.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  3. Article
  4. Review
  5. What you C is what you get.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Cluster-selectiveChemical science · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Niklas B ThompsonDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0003-2745-4945
Gil NamkoongDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-0669-4889
Brighton A SkeelDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0001-8458-088X
Daniel L M SuessDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-0916-1973
Massachusetts Institute of Technology · US

Funding

Chemical Approaches to Studying the Mechanisms and Biophysical Properties of Complex MetallocofactorsR01GM145787 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUESS, DANIEL LEIF MIGDOW · 2022 to 2024
$1.1M
Primary and Secondary Sphere Effects on the Valence Isomerism of Fe-S ClustersF32GM137478 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI THOMPSON, NIKLAS B · 2020 to 2021
$90k
NIGMS NIH HHS F32 GM137478NIGMS NIH HHS R01 GM145787
6 · The paper itself

Abstract

Nature employs weak-field metalloclusters to support a wide range of biological processes. The most ubiquitous metalloclusters are the cuboidal Fe-S clusters, which are comprised of Fe sites with locally high-spin electronic configurations. Such configurations enhance rates of ligand exchange and imbue the clusters with a degree of structural plasticity that is increasingly thought to be functionally relevant. Here, we examine this phenomenon using isotope tracing experiments. Specifically, we demonstrate that synthetic [Fe

Indexed as

iron-sulfur clustersmetallocofactorsMössbauer spectroscopyradical SAM enzymes

Identifiers

PMID36719911
PMCPMC9963086
OpenAlexW4318669718

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.