Evidence map›Paper›PMID 36719597›Full record

ReviewCurrent oncology reports2023

Causes of Clonal Hematopoiesis: a Review.

LiJin Joo, Catherine C Bradley, Steven H Lin, Paul A Scheet, Kevin T Nead

Abstract readReview
In one paragraph

Review in Current oncology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Soiled soil.Blood advances · 2024
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

LiJin JooDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Pressler Street, Houston, TX, 77030, USA.
Catherine C BradleyDepartment of Molecular and Human Genetics, Baylor College of Medicine, 1 Moursund Street, Houston, TX, 77030, USA.
Steven H LinDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Boulevard, Houston, TX, 77030, USA.
Paul A ScheetDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Pressler Street, Houston, TX, 77030, USA.
Kevin T NeadDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Pressler Street, Houston, TX, 77030, USA. ktnead@mdanderson.org.ORCID 0000-0001-9680-8298

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Impact of clonal hematopoiesis mutations on toxicity and outcomes following oncologic therapyK08CA263313 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI NEAD, KEVIN THOMAS · 2021 to 2025
$1.2M
CRYOPROBE FOR 800 MHZ NMR SPECT: STRUC BIOL: BACTERIAL PROTEINS, CARDIAC MUSCLE S10RR019077 · NCRR · UNIVERSITY OF CINCINNATI · PI RANCE, MARK A · 2004 to 2004
$345k
NCI NIH HHS K08 CA263313NCI NIH HHS L30 CA253796NCI NIH HHS P30 CA016672NCRR NIH HHS S10 RR019077
6 · The paper itself

Abstract

purpose of reviewClonal hematopoiesis (CH) is an age-dependent process detectable using advanced sequencing technologies and is associated with multiple adverse health outcomes including cardiovascular disease and cancer. The purpose of this review is to summarize known causes of CH mutations and to identify key areas and considerations for future research on CH. RECENT

findingsStudies have identified multiple potential causes of CH mutations including smoking, cancer therapies, cardiometabolic disease, inflammation, and germline risk factors. Additionally, large-scale studies have facilitated the identification of gene-specific effects of CH mutation risk factors that may have unique downstream health implications. For example, cancer therapies and sources of environmental radiation appear to cause CH through their impact on DNA damage repair genes. There is a growing body of evidence defining risk factors for CH mutations. Standardization in the identification of CH mutations may have important implications for future research. Additional studies in underrepresented populations and their diverse environmental exposures are needed to facilitate broad public health impact of the study of CH mutations.

Indexed as

Clonal HematopoiesisNeoplasmsHematopoiesisHumansMutationRisk FactorsClonal hematopoiesisClonal selection in populationGene and clonal hematopoiesis risk factor associationsMutagensSomatic mutations

Identifiers

PMID36719597
PMCPMC10320845

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.