Evidence map›Paper›PMID 36719438›Full record

ArticleAnalytical and bioanalytical chemistry2023

A label-free dual immunosensor for the simultaneous electrochemical determination of CA125 and HE4 biomarkers for the early diagnosis of ovarian cancer.

Melike Bilgi Kamaç, Muhammed Altun, Merve Yilmaz, Mustafa Kemal Sezgintürk

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In one paragraph

Article in Analytical and bioanalytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

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  13. Sandwich-type electrochemical immunosensing of CA125 by using nanoribbon-like TiAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Melike Bilgi KamaçChemistry Department, Faculty of Science, Çankırı Karatekin University, Çankırı, 18100, Turkey. melikebilgikamac@gmail.com.
Muhammed AltunChemistry Department, Faculty of Science, Çankırı Karatekin University, Çankırı, 18100, Turkey.
Merve YilmazChemistry Department, Faculty of Science, Çankırı Karatekin University, Çankırı, 18100, Turkey.
Mustafa Kemal SezgintürkBioengineering Department, Faculty of Engineering, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. msezginturk@comu.edu.tr.
Çankırı Karatekin University · TRÇanakkale Onsekiz Mart Üniversitesi · TR

Funding

Scientific and Technological Research Institution of Turkey 118R030
6 · The paper itself

Abstract

The blood levels of cancer antigen 125 (CA125) and human epididymal secretory protein 4 (HE4) are measured in the diagnosis and progression monitoring of ovarian cancer (OC), and the Risk of Ovarian Malignancy Algorithm (ROMA) score% values are calculated for cancer risk assessment. For the first time, disposable dual screen-printed carbon electrodes modified with reduced graphene oxide, polythionine, and gold nanoparticles were used to fabricate label-free electrochemical dual CA125-HE4 immunosensors for the sensitive, fast, and practical simultaneous determination of CA125 and HE4. DPV and SWV methods were used to simultaneously determine antigens in two different linear ranges (1-100 pg mL

Indexed as

Biosensing TechniquesMetal NanoparticlesOvarian NeoplasmsBiomarkers, TumorCA-125 AntigenEarly Detection of CancerElectrochemical TechniquesFemaleGoldHumansImmunoassayProteinsWAP Four-Disulfide Core Domain Protein 2Biomarkers, TumorCA-125 AntigenGoldProteinsWAP Four-Disulfide Core Domain Protein 2WFDC2 protein, humanCA125Dual electrochemical immunosensorsHE4Ovarian cancerSimultaneous determination

Identifiers

PMID36719438
OpenAlexW4318591677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.