ReviewThe Journal of antimicrobial chemotherapy2023
Transiently silent acquired antimicrobial resistance: an emerging challenge in susceptibility testing.
Review in The Journal of antimicrobial chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Within-patient carbapenem heteroresistance inCurrent research in microbial sciences · 2026Article
- A novel integrative and conjugative element inmSphere · 2026Article
- Integrated functional genomics and safety assessment of plant-growth-promoting Caryophanales from post-maize-cultivation soils.BMC genomics · 2026Article
- Nanomaterial-nucleic acid probe synergy: accelerating rapid pathogen detection and antimicrobial susceptibility testing in bloodstream infections.Folia microbiologica · 2026Review
- Resistome Profiling of a Large Collection ofInternational journal of molecular sciences · 2026Article
- Genomic and clinical characteristics ofMicrobiology spectrum · 2026Article
- Plasmid-linked virulence genes and high-level gentamicin resistance inJournal of conservative dentistry and endodontics · 2026Article
- Implications of gene expression heterogeneity in the interplay between acquired resistance and bacterial metabolism.Scientific reports · 2025Article
- Antibiotic Resistance in Lactic Acid Bacteria from Dairy Products in Northern Italy.Antibiotics (Basel, Switzerland) · 2025Article
- Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital.International journal of medical microbiology : IJMM · 2024Article
- Antimicrobial and Phylogenomic Characterization ofAntibiotics (Basel, Switzerland) · 2024Article
- Non-Canonical Aspects of Antibiotics and Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2024Review
- Genetic analysis of vancomycin-variable Enterococcus faecium clinical isolates in Italy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Antibiotic Resistance/Susceptibility Profiles ofInternational journal of molecular sciences · 2023Article
- Source Control of Gram-Negative Bacteria Using Self-Disinfecting Sinks in a Swedish Burn Centre.Microorganisms · 2023Article
Corrections and comments
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4 authors.
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Abstract
Acquisition and expression of antimicrobial resistance (AMR) mechanisms in bacteria are often associated with a fitness cost. Thus, evolutionary adaptation and fitness cost compensation may support the advance of subpopulations with a silent resistance phenotype when the antibiotic selection pressure is absent. However, reports are emerging on the transient nature of silent acquired AMR, describing genetic alterations that can change the expression of these determinants to a clinically relevant level of resistance, and the association with breakthrough infections causing treatment failures. This phenomenon of transiently silent acquired AMR (tsaAMR) is likely to increase, considering the overall expansion of acquired AMR in bacterial pathogens. Moreover, the augmented use of genotypic methods in combination with conventional phenotypic antimicrobial susceptibility testing (AST) will increasingly enable the detection of genotype and phenotype discrepancy. This review defines tsaAMR as acquired antimicrobial resistance genes with a corresponding phenotype within the wild-type distribution or below the clinical breakpoint for susceptibility for which genetic alterations can mediate expression to a clinically relevant level of resistance. References to in vivo resistance development and therapeutic failures caused by selected resistant subpopulations of tsaAMR in Gram-positive and Gram-negative pathogens are given. We also describe the underlying molecular mechanisms, including alterations in the expression, reading frame or copy number of AMR determinants, and discuss the clinical relevance concerning challenges for conventional AST.
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