ArticleActa paediatrica (Oslo, Norway : 1992)2023
Postnatal corticosteroids and developmental outcomes in extremely preterm or extremely low birth weight infants: The Victorian Infant Collaborative Study 2016-17 cohort.
Article in Acta paediatrica (Oslo, Norway : 1992), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
- Predicting Dexamethasone-Associated Extubation Success in Preterm Infants.American journal of perinatology · 2026Article
- Threshold Effect of Cumulative Postnatal Corticosteroid Dose on Long-Term Outcomes in Extremely Preterm Infants.Journal of clinical medicine · 2026Article
- Total hydrocortisone dosage in extremely low birth weight infants and neurodevelopment up to school age.Pediatric research · 2026Article
- Article
- Postnatal dexamethasone treatment for preterm infants at high risk for bronchopulmonary dysplasia is associated with improved regional brain volumes: a prospective cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2025Article
- Perinatal Treatment with Corticosteroids and Its Relation with Neurodevelopment in Premature Newborns: A Systematic Review of the Literature.Turkish archives of pediatrics · 2025Article
- Systemic corticosteroid use and neurodevelopmental outcomes in preterm infants: a cohort study.World journal of pediatrics : WJP · 2025Article
- Extracellular Vesicle ASC: A Novel Mediator for Lung-Brain Axis in Preterm Brain Injury.American journal of respiratory cell and molecular biology · 2024Article
- Correlation between Bronchopulmonary Dysplasia and Cerebral Palsy in Children: A Comprehensive Analysis Using the National Inpatient Sample Dataset.Children (Basel, Switzerland) · 2024Article
- The relationship between late (≥ 7 days) systemic dexamethasone and functional network connectivity in very preterm infants.Heliyon · 2023Article
- Impact of bronchopulmonary dysplasia on brain GABA concentrations in preterm infants: Prospective cohort study.Early human development · 2023Article
- Postnatal corticosteroids and developmental outcomes in extremely preterm or extremely low birth weight infants: The Victorian Infant Collaborative Study 2016-17 cohort.Acta paediatrica (Oslo, Norway : 1992) · 2023Article
- Postnatal corticosteroid exposure in very preterm infants: A French cohort study.Frontiers in pharmacology · 2023Article
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11 authors at 5 institutions in 2 countries.
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Abstract
aimSystemic postnatal corticosteroids are used to treat or prevent bronchopulmonary dysplasia (BPD) in extremely preterm (EP) or extremely low birth weight (ELBW) infants but are associated with long-term harm. We aimed to assess the relationship between cumulative postnatal corticosteroid dose and neurodevelopmental outcomes.
methodsLongitudinal cohort study of all EP/ELBW livebirths in Victoria, Australia 2016-2017. Perinatal data were collected prospectively. Neurodevelopmental assessment was performed at 2 years' corrected age. Linear and logistic regression were used to determine relationships between cumulative corticosteroid dose and neurodevelopment, adjusted for gestational age, birth weight, sex and major intraventricular haemorrhage.
resultsSeventy-six EP/ELBW infants received postnatal corticosteroids to treat or prevent BPD, 62/65 survivors were seen at 2 years. Median (IQR) cumulative postnatal corticosteroid dose was 1.36 (0.92-3.45) mg/kg dexamethasone equivalent. Higher cumulative corticosteroid dose was associated with increased odds of cerebral palsy, adjusted OR (95% CI) 1.47 (1.04, 2.07). Higher cumulative corticosteroid dose was also associated with lower cognitive and motor developmental scores, however, this weakened after adjustment for confounding variables: cognitive composite score adjusted coefficient (95% CI) -1.3 (-2.7, 0.1) and motor composite score adjusted coefficient (95% CI) -1.3 (-2.8, 0.2).
conclusionHigher cumulative postnatal corticosteroid dose in EP/ELBW infants is associated with increased odds of cerebral palsy at 2 years' corrected age. Adequately powered studies are needed to assess the independent effects of cumulative steroid dose on neurodevelopmental outcomes.
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