Evidence map›Paper›PMID 36718908›Full record

ArticleJournal of the American Heart Association2023

Genetic Variants Associated With Systolic Blood Pressure in Children and Adolescents.

Mindy M Pike, Jonathan Schildcrout, Scott Baldwin, Todd Edwards, Loren Lipworth, Cassianne Robinson-Cohen

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Association ofGenes · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mindy M PikeDivision of Epidemiology, Department of Medicine Vanderbilt University Medical Center Nashville TN USA.ORCID 0000-0002-7153-868X
Jonathan SchildcroutDepartment of Biostatistics Vanderbilt University Medical Center Nashville TN USA.ORCID 0000-0003-2276-2551
Scott BaldwinDivision of Pediatric Cardiology, Department of Medicine Vanderbilt University Medical Center Nashville TN USA.ORCID 0000-0002-9880-1732
Todd EdwardsDivision of Epidemiology, Department of Medicine Vanderbilt University Medical Center Nashville TN USA.ORCID 0000-0003-4318-6119
Loren LipworthDivision of Epidemiology, Department of Medicine Vanderbilt University Medical Center Nashville TN USA.
Cassianne Robinson-CohenDivision of Nephrology, Department of Medicine Vanderbilt University Medical Center Nashville TN USA.ORCID 0000-0003-4783-7046
Vanderbilt University Medical Center · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Modular Automated -80C Sample Storage SystemS10OD025092 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOLDENRING, JAMES RICHARD · 2019 to 2019
$2.0M
Automated Storage and Retrieval of Biological SystemsS10RR025141 · NCRR · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2008 to 2008
$988k
BioVU Plasma Storage EquipmentS10OD017985 · OD · VANDERBILT UNIVERSITY · PI RODEN, DAN M · 2014 to 2014
$239k
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NIH HHS S10 OD017985NIH HHS S10 OD025092
6 · The paper itself

Abstract

Background Genetics, along with lifestyle and behavioral characteristics, play an important role in hypertension in adults. Our aim was to identify genetic variants associated with blood pressure in childhood and adolescence. Methods and Results We conducted a candidate single-nucleotide polymorphism (SNP) analysis and genome-wide association study among 9778 participants aged <18 years in BioVU, the Vanderbilt University Medical Center biobank. The outcome was childhood blood pressure percentile from age 0 to 18 years. For the candidate SNP analysis, a total of 457 previously identified SNPs were examined. Linear regression was used to test the association between genetic variants and median systolic blood pressure (SBP) percentile. Adjusted models included median age, self-reported sex, race, the first 4 principal components of ancestry, and median body mass index

Indexed as

Blood PressureGenome-Wide Association StudyHypertensionAdolescentChildChild, PreschoolHumansLinear ModelsPlasma Membrane Calcium-Transporting ATPasesPolymorphism, Single NucleotideRisk FactorsATP2B1 protein, humanPlasma Membrane Calcium-Transporting ATPaseschildhoodgenome‐wide association studysingle‐nucleotide polymorphismsystolic blood pressure

Identifiers

PMID36718908
PMCPMC9973622
OpenAlexW4318617161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.