Evidence map›Paper›PMID 36718584›Full record

ArticleHealth psychology review2023

Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions.

George M Slavich, Lydia G Roos, Summer Mengelkoch, Christian A Webb, Eric C Shattuck, Daniel P Moriarity, Jenna C Alley

Open access · hybridAbstract read
In one paragraph

Article in Health psychology review, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 3 pooled it
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Stress and cardiovascular disease: Testing a vigilance pathway in two contemporary theories.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Article
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  8. Obesity-related RNA mJournal of neural transmission (Vienna, Austria : 1996) · 2026
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

George M SlavichDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.ORCID 0000-0001-5710-3818
Lydia G RoosDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.ORCID 0000-0003-4688-5687
Summer MengelkochDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.ORCID 0000-0002-1845-2107
Christian A WebbMcLean Hospital, Belmont, MA, USA.ORCID 0000-0002-8310-4539
Eric C ShattuckInstitute for Health Disparities Research and Department of Public Health, University of Texas at San Antonio, San Antonio, TX, USA.ORCID 0000-0002-3615-5931
Daniel P MoriarityDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.ORCID 0000-0001-8678-7307
Jenna C AlleyDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.ORCID 0000-0001-8410-9860
University of California, Los Angeles · USHarvard University · USThe University of Texas at San Antonio · US

Funding

Stress, diet quality, and biological aging across the lifespanR24AG048024 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S., MENDES, WENDY BERRY · 2014 to 2025
$6.2M
Supplemental: Neural and cognitive propensity for trait rumination in adolescents: a multimodal study with ecological momentary assessments and MRIR01AT011002 · NCCIH · MCLEAN HOSPITAL · PI WEBB, CHRISTIAN ANTHONY · 2021 to 2025
$3.4M
Predicting the onset of depression in at-risk adolescents from endophenotype profilesR01MH116969 · NIMH · MCLEAN HOSPITAL · PI WEBB, CHRISTIAN ANTHONY · 2019 to 2024
$2.8M
Neural, Inflammatory, and Genomic Mechanisms Underlying Risk for Depression in AdolescenceK08MH103443 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SLAVICH, GEORGE MICHAEL · 2015 to 2018
$772k
Testing a Social Safety Theory Perspective on Depression: An Intensive Longitudinal Immunopsychiatric Data ApproachF32MH130149 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORIARITY, DANIEL P · 2022 to 2024
$210k
NCCIH NIH HHS R01 AT011002NIA NIH HHS R24 AG048024NIMH NIH HHS F32 MH130149NIMH NIH HHS K08 MH103443NIMH NIH HHS R01 MH116969
6 · The paper itself

Abstract

Classic theories of stress and health are largely based on assumptions regarding how different psychosocial stressors influence biological processes that, in turn, affect human health and behavior. Although theoretically rich, this work has yielded little consensus and led to numerous conceptual, measurement, and reproducibility issues. Social Safety Theory aims to address these issues by using the primary goal and regulatory logic of the human brain and immune system as the basis for specifying the social-environmental situations to which these systems should respond most strongly to maximize reproductive success and survival. This analysis gave rise to the integrated, multi-level formulation described herein, which transforms thinking about stress biology and provides a biologically based, evolutionary account for how and why experiences of social safety and social threat are strongly related to health, well-being, aging, and longevity. In doing so, the theory advances a testable framework for investigating the biopsychosocial roots of health disparities as well as how health-relevant biopsychosocial processes crystalize over time and how perceptions of the social environment interact with childhood microbial environment, birth cohort, culture, air pollution, genetics, sleep, diet, personality, and self-harm to affect health. The theory also highlights several interventions for reducing social threat and promoting resilience.

Indexed as

BrainSocial EnvironmentChildHumansReproducibility of ResultsBiologyDevelopmentDiseaseHealthResilienceStress

Identifiers

PMID36718584
PMCPMC10161928
OpenAlexW4318671511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.