Evidence map›Paper›PMID 36718474›Full record

ArticleLaryngoscope investigative otolaryngology2022

A multicenter real-life study to determine the efficacy of corticosteroids and olfactory training in improving persistent COVID-19-related olfactory dysfunction.

Alfonso Luca Pendolino, Giancarlo Ottaviano, Juman Nijim, Bruno Scarpa, Giulia De Lucia, Cecilia Berro, Piero Nicolai, Peter J Andrews

Abstract read
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Treatments for Olfactory Dysfunction in COVID-19: A Systematic Review.International archives of otorhinolaryngology · 2024
    Review
  5. Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alfonso Luca PendolinoDepartment of ENT Royal National ENT & Eastman Dental Hospitals London UK.ORCID https://orcid.org/0000-0002-6348-5303
Giancarlo OttavianoDepartment of Neurosciences, Otolaryngology Section University of Padova Padova Italy.ORCID https://orcid.org/0000-0003-2433-4761
Juman NijimUniversity College London Medical School London UK.
Bruno ScarpaDepartment of Statistical Sciences and Department of Mathematics Tullio Levi-Civita University of Padova Padova Italy.
Giulia De LuciaDepartment of Neurosciences, Otolaryngology Section University of Padova Padova Italy.
Cecilia BerroDepartment of Neurosciences, Otolaryngology Section University of Padova Padova Italy.
Piero NicolaiDepartment of Neurosciences, Otolaryngology Section University of Padova Padova Italy.
Peter J AndrewsDepartment of ENT Royal National ENT & Eastman Dental Hospitals London UK.ORCID https://orcid.org/0000-0001-5731-3276

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: No definitive treatment exists to effectively restore function in patients with persistent post-infectious olfactory dysfunction (OD). Corticosteroids have been considered as a therapeutic option in post-infectious OD but their benefit in COVID-19-related OD remains unexplored. We aim to determine the role of the combination of corticosteroids plus olfactory training (OT) in improving persistent COVID-19-related OD. Methods: A multicenter real-life cohort study was conducted between December 2020 and April 2022 on patients with reported COVID-19-related OD. Only patients with confirmed OD at Sniffin' Sticks (S'S) and those who attended their 6-month follow-up were included. Patients were started on a combined treatment of corticosteroids and OT. Patients refusing corticosteroids or not doing any treatment formed the control groups. Visual analogue scale (VAS) for sense of smell and SNOT-22 were used to assess patients reported symptoms. Results: Sixty-seven subjects with reported COVID-19-related OD were initially seen. Normosmic patients at S'S ( Conclusions: Our study confirms the importance of OT in long-term OD suggesting that the addition of corticosteroids may give a benefit in terms of patient's perceived olfaction. Level of Evidence: 2b.

Indexed as

corticosteroidsCOVID‐19olfactionolfactory trainingsmell

Identifiers

PMID36718474
PMCPMC9877766

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.