Evidence map›Paper›PMID 36718389›Full record

ReviewJournal of oral biology and craniofacial research

Role of hormones in bone remodeling in the craniofacial complex: A review.

Erin Grinde Tunheim, Hans Erling Skallevold, Dinesh Rokaya

Open access · goldAbstract readReview
In one paragraph

Review in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. TheFrontiers in medicine · 2025
    Review
  12. The Molecular Comorbidity Network of Periodontal Disease.International journal of molecular sciences · 2024
    Article
  13. Article
  14. Role of oxytocin in bone.Frontiers in endocrinology · 2024
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. The Influence of Implant Macro-geometry in Primary Stability in Low-Density Bone: AnJournal of International Society of Preventive & Community Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Erin Grinde TunheimDepartment of Clinical Dentistry, Faculty of Health Sciences, UIT the Arctic University of Norway, 9037, Tromsö, Norway.
Hans Erling SkallevoldDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand.
Dinesh RokayaDepartment of Clinical Dentistry, Walailak University International College of Dentistry, Walailak University, Bangkok 10400, Thailand.
Chulalongkorn University · THUiT The Arctic University of Norway · NOWalailak University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diseases such as periodontitis and osteoporosis are expected to rise tremendously by 2050. Bone formation and remodeling are complex processes that are disturbed in a variety of diseases influenced by various hormones. Objective: This study aimed to review and present the roles of various hormones that regulate bone remodeling of the craniofacial complex. Methods: A literature search was conducted on PubMed and Google Scholar for studies related to hormones and jawbone. Search strategies included the combinations ("name of hormone" + "dental term") of the following terms: "hormones", "oxytocin", "estrogen", "adiponectin", "parathyroid hormone", "testosterone", "insulin", "angiotensin", "cortisol", and "erythropoietin", combined with a dental term "jaw bone", "alveolar bone", "dental implant", "jaw + bone regeneration, healing or repair", "dentistry", "periodontitis", "dry socket", "osteoporosis" or "alveolitis". The papers were screened according to the inclusion criteria from January 1, 2000 to March 31, 2021 in English. Publications included reviews, book chapters, and original research papers; Results: Bone formation and remodeling is a complex continuous process involving many hormones. Bone volume reduction following tooth extractions and bone diseases, such as periodontitis and osteoporosis, cause serious problems and require a great understanding of the process. Conclusion: Hormones are with us all the time, shape our development and regulate homeostasis. Newly discovered effects of hormones influencing bone healing open the possibilities of using hormones as therapeutics to combat bone-related diseases.

Indexed as

ACE2/Ang-(1-7)/MasR, ACE 2/angiotensin-(1-7)/mas receptorACE, Angiotensin-converting enzymeAD, AndrogensAGEs, Advanced glycation end-productsAN, AdiponectinBone formationBone homeostasisBone regenerationBone resportionDHT, DihydrotestosteroneDIZE, Diminazene aceturateDM, Diabetes mellitusEPO, ErythropoietinER, Estrogen receptorsERα, ER alphaERβ, ER betaES, EstrogenGPER1, G-protein coupled estrogen receptor 1HIF-PHIs, Hypoxia inducible factor-prolyl hydroxylase inhibitorsHormonesIGF-1, Insulin-like growth factor-1JawboneMAPK, Mitogen-activated protein kinaseOT, OxytocinPTH, Parathyroid hormoneRAGEs, Receptor advanced glycation end-productsRANKL, Receptor activator of NF-κB ligandRAS, Renin-angiotensin systemVEGF, Vascular endothelial growth factor

Identifiers

PMID36718389
PMCPMC9883279
OpenAlexW4317634751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.