ArticleiScience2023
Temporal synchronization elicits enhancement of binocular vision functions.
Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Non-Synaptic Mechanism of Ocular Dominance Plasticity.ASN neuro · 2026Article
- Intact Perceptual Interactions of Interocular Temporal Phase and Contrast Disparities in Amblyopia.Investigative ophthalmology & visual science · 2025Article
- The Relationship Between Binocular Imbalance and Myopic Shift in Unoperated Eyes After Unilateral SMILE and tPRK.Investigative ophthalmology & visual science · 2025Article
- Contextual Binocular Imbalance Impairs Local Stereopsis.Investigative ophthalmology & visual science · 2025Article
- Effects of Monocular Flicker on Binocular Imbalance in Amblyopic and Nonamblyopic Adults.Investigative ophthalmology & visual science · 2024Article
- Measuring the Interocular Delay and its Link to Visual Acuity in Amblyopia.Investigative ophthalmology & visual science · 2024Article
- Perceptual learning based on a temporal stimulus enhances visual function in adult amblyopic subjects.Scientific reports · 2023Article
- Spatial frequency channels depend on stimulus bandwidth in normal and amblyopic vision: an exploratory factor analysis.Frontiers in computational neuroscience · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integration of information over the CNS is an important neural process that affects our ability to perceive and react to the environment. The visual system is required to continuously integrate information arriving from two different sources (the eyes) to create a coherent percept with high spatiotemporal precision. Although this neural integration of information is assumed to be critical for visual performance, it can be impaired under some pathological or developmental conditions. Here we took advantage of a unique developmental condition, amblyopia ("lazy eye"), which is characterized by an impaired temporal synchronization between the two eyes, to meticulously study the effect of synchronization on the integration of binocular visual information. We measured the eyes' asynchrony and compensated for it (with millisecond temporal resolution) by providing time-shifted stimuli to the eyes. We found that the re-synchronization of the ocular input elicited a significant improvement in visual functions, and binocular functions, such as binocular summation and stereopsis, were regained. This phenomenon was also evident in neurophysiological measures. Our results can shed light on other neural processing aspects and might also have translational relevance for the field of training, rehabilitation, and perceptual learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.