Evidence map›Paper›PMID 36718152›Full record

ArticleHeliyon2023

Profiling of peripheral blood B-cell transcriptome in children who developed coeliac disease in a prospective study.

Astrid Oras, Henna Kallionpää, Tomi Suomi, Satu Koskinen, Asta Laiho, Laura L Elo, Mikael Knip, Riitta Lahesmaa, Alar Aints, Raivo Uibo and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Astrid OrasDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.
Henna KallionpääTurku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.
Tomi SuomiTurku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.
Satu KoskinenTurku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.
Asta LaihoTurku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.
Laura L EloTurku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.
Mikael KnipPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Riitta LahesmaaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.
Alar AintsDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.
Raivo UiboDepartment of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia.
DIABIMMUNE Study Group
Åbo Akademi University · FIUniversity of Tartu · EEUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In coeliac disease (CoD), the role of B-cells has mainly been considered to be production of antibodies. The functional role of B-cells has not been analysed extensively in CoD. Methods: We conducted a study to characterize gene expression in B-cells from children developing CoD early in life using samples collected before and at the diagnosis of the disease. Blood samples were collected from children at risk at 12, 18, 24 and 36 months of age. RNA from peripheral blood CD19 Findings: Overall, we found one gene, Interpretation: The data highlight the role of B-cells in CoD development. The role of HNRPL in suppressing enteroviral replication suggests that the predisposing factor for both CoD and enteroviral infections is the low level of Funding: EU FP7 grant no. 202063, EU Regional Developmental Fund and research grant PRG712, The Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (SyMMyS) 2012-2017, grant no. 250114) and, AoF Personalized Medicine Program (grant no. 292482), AoF grants 292335, 294337, 319280, 31444, 319280, 329277, 331790) and grants from the Sigrid Jusélius Foundation (SJF).

Indexed as

B-cellsCoeliac diseaseHigh-throughput mRNA sequencing

Identifiers

PMID36718152
PMCPMC9883278
OpenAlexW4317633828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.