Evidence map›Paper›PMID 36717812›Full record

ArticleBMC veterinary research2023

Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia.

Mariem Handous, Imed Turki, Abdejelil Ghram, Samia BenMaiz, Jihen Bensalem, Nourhene Basdouri, Mohamed Soltani, Farah Bassalah, Habib Kharmachi

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mariem HandousUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia. mariem.handous@pasteur.tn.
Imed TurkiUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia.
Abdejelil GhramUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia.
Samia BenMaizUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia.
Jihen BensalemUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia.
Nourhene BasdouriUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia.
Mohamed SoltaniUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia.
Farah BassalahUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia.
Habib KharmachiUniversity of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia.
Institut Pasteur de Tunis · TNTunis El Manar University · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRabies (RABV) is an enzootic disease in Tunisia, with dogs being the primary reservoir. Vaccinating dogs is the key to eradicate rabies. Regional Veterinary Services conduct nationwide immunisation campaigns on an annual basis. Evaluation of the immune response is still important to make sure that the vaccination is effective in the conditions of the Tunisian field. In this paper, the FAVN technique was used to test rabies antibody dynamics in dogs from three distinct Tunisian areas observed for one year following a mass vaccination campaign.

resultsOn day 30 after vaccination, 75% of all dogs vaccinated during the campaign were sero-positive (titres greater than or equal to 0.5 transformed IU/ml). On day 180, 48% of all dogs were sero-positive. Only 25.6% of primary-vaccinated dogs remained sero-positive on day 180 and 7% on day 365, whereas 91% of previously sero-positive dogs remained sero-positive on day 365.

conclusionsAlthough a single rabies vaccine is successful at stimulating an immunological response, it is recommended that primary-vaccinated dogs have a second booster between one and three months after the initial vaccination to maintain seropositivity. To achieve the rabies eradication objective, all dogs should receive an annual booster to maintain effective immunological protection.

Indexed as

Dog DiseasesRabiesRabies VaccinesAnimalsAntibodies, ViralDogsImmunityImmunization ProgramsMass VaccinationTunisiaVaccinationAntibodies, ViralRabies VaccinesDogsFAVNImmune responseRabies virus

Identifiers

PMID36717812
PMCPMC9885660
OpenAlexW4318475265

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.