ArticleNature communications2023
Exocytosis of the silicified cell wall of diatoms involves extensive membrane disintegration.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- The morphogenetic activity of dAnk genes in the diatom Thalassiosira pseudonana is sensitive to Si availability.Communications biology · 2026Article
- Structural Insights into Cell Wall-Related Vesicle Secretion with Different Mechanisms.Plants (Basel, Switzerland) · 2026Article
- Morphology and mechanical behavior of diatoms in wet and dry states studied using nano-XCT.BMC biology · 2025Article
- Reminiscent of the pre-diatom? A hitherto undescribed scaly bolidophyte Lepidoparma frigida gen. et sp. nov. in a new order Lepidoparmales based on morphology, phylogeny, and ecology.Journal of phycology · 2025Article
- Mechanics control the proliferation of diatoms entrapped in hydrogels.Soft matter · 2025Article
- Big evolutionary fireworks in tiny glass houses.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Harnessing Microalgae as Sustainable Cell Factories for Polyamine-Based Nanosilica for Biomedical Applications.Molecules (Basel, Switzerland) · 2025Review
- Hexagonal Patterns in Diatom Silica Form via a Directional Two-Step Process.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Intracellular morphogenesis of diatom silica is guided by local variations in membrane curvature.Nature communications · 2024Article
- Transcriptomic analysis reveals the mechanism underlying salinity-induced morphological changes inFrontiers in microbiology · 2024Article
- Enhancement of hemostatic properties of Cyclotella cryptica frustule through genetic manipulation.Biotechnology for biofuels and bioproducts · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diatoms are unicellular algae characterized by silica cell walls. These silica elements are known to be formed intracellularly in membrane-bound silica deposition vesicles and exocytosed after completion. How diatoms maintain membrane homeostasis during the exocytosis of these large and rigid silica elements remains unknown. Here we study the membrane dynamics during cell wall formation and exocytosis in two model diatom species, using live-cell confocal microscopy, transmission electron microscopy and cryo-electron tomography. Our results show that during its formation, the mineral phase is in tight association with the silica deposition vesicle membranes, which form a precise mold of the delicate geometrical patterns. We find that during exocytosis, the distal silica deposition vesicle membrane and the plasma membrane gradually detach from the mineral and disintegrate in the extracellular space, without any noticeable endocytic retrieval or extracellular repurposing. We demonstrate that within the cell, the proximal silica deposition vesicle membrane becomes the new barrier between the cell and its environment, and assumes the role of a new plasma membrane. These results provide direct structural observations of diatom silica exocytosis, and point to an extraordinary mechanism in which membrane homeostasis is maintained by discarding, rather than recycling, significant membrane patches.
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