Evidence map›Paper›PMID 36717479›Full record

ArticleMolecular neurobiology2023

Evaluating the Genetic Role of Circadian Clock Genes in Parkinson's Disease.

Yaqin Xiang, JuanJuan Huang, Yige Wang, XiuRong Huang, Qian Zeng, Lizhi Li, Yuwen Zhao, Hongxu Pan, Qian Xu, Zhenhua Liu and 9 more

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Clock gene Per2 modulates epidermal tissue repair in vivo.Journal of cellular biochemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Yaqin Xiang *Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
JuanJuan Huang *Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yige WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
XiuRong HuangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qian ZengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lizhi LiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yuwen ZhaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hongxu PanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qian XuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhenhua LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qiying SunDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Junling WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jieqiong TanKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China.
Lu ShenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hong JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xinxiang YanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jinchen LiDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jifeng GuoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China. guojifeng2003@163.com.ORCID http://orcid.org/0000-0002-3658-3928
Central South University · CN

Funding

Hunan Innovative Province Construction Project 2019SK2335Innovation-Driven Project of Central South University 2020CX016Innovative team program from Department of Science & Technology of Hunan Province 2019RS1010National Key Research and Development Program of China 2021YFC2501204National Natural Science Foundation of China 81873785National Natural Science Foundation of China 81974202National Natural Science Foundation of China 82001359National Natural Science Foundation of China 82071439National Natural Science Foundation of China U20A20355Technology Major Project of Hunan Provincial Science and Technology Department 2021SK1010
6 · The paper itself

Abstract

Increasing evidence suggests that circadian dysfunction is related to Parkinson's disease (PD). However, the role of circadian clock genes in PD is still poorly understood. This study aimed to illustrate the association between genetic variants of circadian clock genes and PD in a large Chinese population cohort. Ten circadian clock genes were included in this study. Whole-exome sequencing (WES) was conducted in 1997 early-onset or familial PD patients and 1652 controls (WES cohort), and whole-genome sequencing (WGS) was conducted in 1962 sporadic late-onset PD patients and 1279 controls (WGS cohort). Analyses were completed using the optimized sequence kernel association test and regression analyses. In the burden analysis of the circadian clock gene set, we found suggestive significant associations between the circadian clock genes and PD in the WES cohort when considering missense, damaging missense (Dmis), and deleterious variants. Moreover, the burden analysis of single genes revealed suggestive significant associations between PD and the loss-of-function variants of the CRY1 gene, missense, Dmis, and deleterious variants of the PER1 gene, and Dmis and deleterious variants of the PER2 gene in the WES cohort. Rare variants in the WGS cohort and all common variants in the WGS and WES cohorts were unrelated to PD. Phenotypic analysis indicated that deleterious variants of the PER1 gene were associated with dyskinesia in the WES cohort. Our study provides evidence of a potential link between circadian clock genes and PD from a genetic perspective.

Indexed as

Circadian ClocksParkinson DiseaseAsian PeopleExome SequencingHumansCircadian clock genesCommon variantNext-generation sequencingParkinson’s diseaseRare variant

Identifiers

PMID36717479
OpenAlexW4318578600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.