Evidence map›Paper›PMID 36717425›Full record

Trial reportClinical oral investigations2023

Local gingival crevicular fluid, synovial fluid, and circulating levels of prolactin hormone in patients with moderately active rheumatoid arthritis and stage III and IV periodontitis before and after non-surgical periodontal treatment-a controlled trial.

Naglaa Mohamed El-Wakeel, Zienab Farid Shalaby, Rania Farouk Abdulmaguid, Sally Said Abd Elhamed, Olfat Shaker

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04279691 (Synovial and Gingival Crevicular Fluid Levels of Prolactin Hormone in Rheumatoid Arthritis Patients With Periodontitis), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04279691 unknown statusnot on this map

Synovial and Gingival Crevicular Fluid Levels of Prolactin Hormone in Rheumatoid Arthritis Patients With Periodontitis

TypeobservationalSponsorOctober University for Modern Sciences and ArtsRan2020 to 2020Enrolled30ConditionsRheumatoid Arthritis, Periodontitis
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Naglaa Mohamed El-WakeelOral Medicine and Periodontology Department, Faculty of Dentistry, Al-Azhar University (Girls Branch), Al-Mokhayam El Dayem St., Nasr City, 1178, Cairo, Egypt. naglaelwakeel@gmail.com.
Zienab Farid ShalabyOral Medicine and Periodontology Department, Faculty of Dentistry, Al-Azhar University (Girls Branch), Al-Mokhayam El Dayem St., Nasr City, 1178, Cairo, Egypt.
Rania Farouk AbdulmaguidOral Medicine and Periodontology Department, Faculty of Dentistry, October University for Modern Sciences and Arts, Giza, Egypt.
Sally Said Abd ElhamedInternal Medicine Department, Faculty of Medicine, Al-Azhar University (Girls Branch), Cairo, Egypt.
Olfat ShakerMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Al-Azhar University · EGCairo University · EGOctober University of Modern Sciences and Arts · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to investigate prolactin (PRL) levels in gingival crevicular fluid (GCF), synovial fluid, and serum in patients suffering from moderately active rheumatoid arthritis (RA) with and without periodontitis (P). Further, to evaluate the effect of non-surgical periodontal treatment on these levels compared to controls. MATERIALS AND

methodsEighty subjects were divided into 4 groups: group 1: 20 patients with RA + P, group 2: 20 periodontitis patients (systemically healthy), group 3: RA patients (periodontally healthy), and group 4: healthy controls. Patients with periodontitis received scaling and root planning (SRP). PRL was measured using enzyme-linked immunosorbent assay.

resultsAt baseline, in GCF of RA + P group showed the highest mean PRL levels, followed by P group whereas groups 3 and 4 showed a statistically less values than the first 2 groups. Serum values showed non-significant difference between the first three groups, although higher than healthy controls. SRP reduced GCF and serum levels of PRL in both P groups as well as synovial fluid PRL in group 1. SRP caused no change in DAS scores while reduced ESR values were observed in group 1 after treatment.

conclusionsLocal GCF and synovial levels of PRL seem to be linked to the disease process of both periodontitis and rheumatoid arthritis than serum levels. SRP reduced these local levels. CLINICAL RELEVANCE: In patients with RA and CP, local PRL seems to play a role in the association between the two conditions; further, periodontal treatment is essential to improve periodontal condition in RA patients.

trial registrationClinicaltrials.gov. Identifier: NCT04279691.

Indexed as

Arthritis, RheumatoidChronic PeriodontitisPeriodontitisGingival Crevicular FluidHumansProlactinSynovial FluidProlactinGingival crevicular fluidPeriodontitisProlactinRheumatoid arthritisSynovial fluid

Identifiers

PMID36717425
PMCPMC10264271
OpenAlexW4318670815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.