ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
Influence of Microgel and Interstitial Matrix Compositions on Granular Hydrogel Composite Properties.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
41 citing papers in PubMed.
- Granular Hydrogel Composites as Matrices for Engineered Living Materials.ACS applied polymer materials · 2026Article
- Reconciling Granular Hydrogel Microstructure and Mechanics via a Temporary Thermo-Responsive and Cell-Invadable Matrix.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Integrating microchannels and flows into 3D printable granular hydrogel matrices.Lab on a chip · 2026Article
- Fatigue-resistant and tough double network granular elastomers.Science advances · 2026Article
- Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization.Nature materials · 2026Article
- Microgel-Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function.Advanced healthcare materials · 2026Review
- Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration.Advanced healthcare materials · 2026Article
- Bioinstructive Orthogonally-crosslinked Ovoprotein Microgels for Modular Bioprinting.bioRxiv : the preprint server for biology · 2026Article
- Clickable Microgel Inks Enable Spatioselective, Multi-Stimuli Programmable Assembly of Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chitosan- and Gelatin-Based Composite Granular Hydrogels for Cartilage Tissue Regeneration.International journal of molecular sciences · 2026Article
- Dynamic granular hydrogels to assess pancreatic cancer cell fate.Biomaterials science · 2026Article
- Bioactive and Injectable Granular Hydrogels Incorporating Decellularized Extracellular Matrix.ACS biomaterials science & engineering · 2026Article
- Reliable AI Platform for Monitoring BCI Caused Brain Injury and Providing Real-Time Protection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Enzyme-induced mineralization of calcium carbonate in 3D printable granular hydrogels.Advanced composites and hybrid materials · 2026Article
- Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses.Advanced healthcare materials · 2026Review
- Injectable micropore-forming microgel scaffold for neural progenitor cells transplantation and vascularization after stroke.Nature communications · 2025Article
- A biofabricated 3D cancer-stroma tumor microenvironment model.Biofabrication · 2025Article
- Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments.Advanced healthcare materials · 2025Review
- Multiscale Engineered Heterogeneous Hydrogel Composites for Digital Light Processing 3D Printing.ACS applied materials & interfaces · 2025Article
- Particle-based hydrogel inks and support matrices for biofabricating structural complexity, soluble gradients, and cell-lined channels in fully granular bioprinted systems.Biofabrication · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Granular hydrogels are an emerging class of biomaterials formed by jamming hydrogel microparticles (i.e., microgels). These materials have many advantageous properties that can be tailored through microgel design and extent of packing. To enhance the range of properties, granular composites can be formed with a hydrogel interstitial matrix between the packed microgels, allowing for material flow and then stabilization after crosslinking. This approach allows for distinct compartments (i.e., microgels and interstitial space) with varied properties to engineer complex material behaviors. However, a thorough investigation of how the compositions and ratios of microgels and interstitial matrices influence material properties has not been performed. Herein, granular hydrogel composites are fabricated by combining fragmented hyaluronic acid (HA) microgels with interstitial matrices consisting of photocrosslinkable HA. Microgels of varying compressive moduli (10-70 kPa) are combined with interstitial matrices (0-30 vol.%) with compressive moduli varying from 2-120 kPa. Granular composite structure (confocal imaging), mechanics (local and bulk), flow behavior (rheology), and printability are thoroughly assessed. Lastly, variations in the interstitial matrix chemistry (covalent vs guest-host) and microgel degradability are investigated. Overall, this study describes the influence of granular composite composition on structure and mechanical properties of granular hydrogels towards informed designs for future applications.
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