Evidence map›Paper›PMID 36717247›Full record

ArticleLife science alliance2023

Mature B cells and mesenchymal stem cells control emergency myelopoiesis.

Vivian Y Lim, Xing Feng, Runfeng Miao, Sandra Zehentmeier, Nathan Ewing-Crystal, Moonyoung Lee, Alexei V Tumanov, Ji Eun Oh, Akiko Iwasaki, Andrew Wang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Vivian Y LimDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Xing FengDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Runfeng MiaoDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Sandra ZehentmeierDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Nathan Ewing-CrystalDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Moonyoung LeeDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul, South Korea.ORCID https://orcid.org/0000-0002-3569-4351
Alexei V TumanovDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.ORCID https://orcid.org/0000-0001-6042-0152
Ji Eun OhDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.ORCID https://orcid.org/0000-0003-2511-7064
Akiko IwasakiDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-7824-9856
Andrew WangDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Jungmin ChoiDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul, South Korea joao.pereira@yale.edu jungminchoi@korea.ac.kr.ORCID https://orcid.org/0000-0002-8614-0973
João P PereiraDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA joao.pereira@yale.edu jungminchoi@korea.ac.kr.ORCID https://orcid.org/0000-0002-5694-4938
Yale University · USKorea University · KRHoward Hughes Medical Institute · USThe University of Texas Health Science Center at San Antonio · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Training Program in Investigative HepatologyT32DK007356 · NIDDK · YALE UNIVERSITY · PI MICHAEL H NATHANSON · 1986 to 2026
$7.4M
Cellular and molecular analysis of B lymphocyte development and selectionR01AI113040 · NIAID · YALE UNIVERSITY · PI JOAO PEREIRA · 2014 to 2026
$6.0M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI113040NIDDK NIH HHS T32 DK007356
6 · The paper itself

Abstract

Systemic inflammation halts lymphopoiesis and prioritizes myeloid cell production. How blood cell production switches from homeostasis to emergency myelopoiesis is incompletely understood. Here, we show that lymphotoxin-β receptor (LTβR) signaling in combination with TNF and IL-1 receptor signaling in bone marrow mesenchymal stem cells (MSCs) down-regulates

Indexed as

Mesenchymal Stem CellsMyelopoiesisB-LymphocytesHumansInflammationInterleukin-7Interleukin-7

Identifiers

PMID36717247
PMCPMC9889502
OpenAlexW4318499636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.