Evidence map›Paper›PMID 36717165›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2023

Adrenergic control of skeletal muscle blood flow during chronic hypoxia in healthy males.

Lydia L Simpson, Alexander B Hansen, Gilbert Moralez, Sachin B Amin, Florian Hofstaetter, Christopher Gasho, Mike Stembridge, Tony G Dawkins, Michael M Tymko, Philip N Ainslie and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Does endothelial ischemic reperfusion injury augment sympathetic neurovascular transduction?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 5 countries.

Lydia L SimpsonDepartment of Sport Science, Division of Performance Physiology and Prevention, Universität Innsbruck, Innsbruck, Austria.ORCID 0000-0002-0357-6561
Alexander B HansenDepartment of Sport Science, Division of Performance Physiology and Prevention, Universität Innsbruck, Innsbruck, Austria.ORCID 0000-0001-6747-3708
Gilbert MoralezDepartment of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0002-0654-2383
Sachin B AminDepartment of Sport Science, Division of Performance Physiology and Prevention, Universität Innsbruck, Innsbruck, Austria.ORCID 0000-0002-6131-309X
Florian HofstaetterDepartment of Sport Science, Division of Performance Physiology and Prevention, Universität Innsbruck, Innsbruck, Austria.
Christopher GashoDepartment of Medicine, Division of Pulmonary and Critical Care, Loma Linda University, Loma Linda, California, United States.
Mike StembridgeCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, Wales, United Kingdom.ORCID 0000-0003-0818-6420
Tony G DawkinsCentre of Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.ORCID 0000-0001-5203-135X
Michael M TymkoCentre of Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Philip N AinslieCentre of Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Justin S LawleyDepartment of Sport Science, Division of Performance Physiology and Prevention, Universität Innsbruck, Innsbruck, Austria.ORCID 0000-0003-2166-7966
Christopher M HearonDepartment of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0002-6561-3532
Universität Innsbruck · ATUniversity of British Columbia · CACardiff Metropolitan University · GBEurac Research · ITLoma Linda University · USTexas Health Dallas · USThe University of Texas Southwestern Medical Center · US

Funding

Abnormal Vascular, Metabolic, and Neural Function During Exercise in Heart Failure with Preserved Ejection FractionF32HL137285 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HEARON, CHRISTOPHER M · 2017 to 2020
$200k
NHLBI NIH HHS F32 HL137285
6 · The paper itself

Abstract

Sympathetic transduction is reduced following chronic high-altitude (HA) exposure; however, vascular α-adrenergic signaling, the primary mechanism mediating sympathetic vasoconstriction at sea level (SL), has not been examined at HA. In nine male lowlanders, we measured forearm blood flow (Doppler ultrasound) and calculated changes in vascular conductance (ΔFVC) during

Indexed as

Adrenergic AgentsVasoconstrictionHumansHypoxiaMaleMuscle, SkeletalPhenylephrineRegional Blood FlowVasoconstrictor AgentsAdrenergic AgentsPhenylephrineVasoconstrictor Agentsexercisehigh altitudeskeletal muscle blood flowsympathetic nervous systemα-adrenergic receptors

Identifiers

PMID36717165
PMCPMC10026988
OpenAlexW4318571806

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.