SynthesisJournal of thrombosis and haemostasis : JTH2023
DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Journal of thrombosis and haemostasis : JTH, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
What it found
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- DNA Methylation Variation in Blood Cells may Impact Platelet Function.TH open : companion journal to thrombosis and haemostasis · 2026Article
- DNA methylation predicts adverse outcomes of coronary artery disease.Nature communications · 2025Article
- DNA Methylation Signatures of Systemic Inflammation Are Associated With Brain Volume, Cognitive Trajectories, and Long-Term Dementia Risk.Aging cell · 2025Article
- DNA methylation markers of insulin resistance surrogate measures in the Atherosclerosis Risk in Communities (ARIC) study.Epigenetics · 2025Article
- Epidemiology, fibrinogen, clot properties, and cardiovascular disease risk-an African perspective.Research and practice in thrombosis and haemostasis · 2025Article
- The Association Study of Targeted DNA Methylation and Thrombophilia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Evaluation of the HumanMethylationEPIC v2.0 Bead Chip Using Low Quality and Quantity DNA Samples.Biological procedures online · 2025Article
- Article
- Regulation of fibrinogen synthesis.Thrombosis research · 2024Review
- The emerging role of fibrin(ogen) in cardiovascular disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Review
- Circulating microRNAs and DNA Methylation as Regulators of Direct Oral Anticoagulant Response in Atrial Fibrillation and Key Elements for the Identification of the Mechanism of Action (miR-CRAFT): Study Design and Patient Enrolment.Journal of personalized medicine · 2024Article
- Fibrinogen and tumors.Frontiers in oncology · 2024Review
- Fibrinogen and fibrin: synthesis, structure, and function in health and disease.Journal of thrombosis and haemostasis : JTH · 2023Review
Corrections and comments
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Authors and funding
58 authors at 20 institutions in 9 countries.
Julie HahnHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA. Electronic address: Julie.M.Hahn@uth.tmc.edu.
Jan BresslerHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Arce Domingo-RellosoDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA; Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institutes, Madrid, Spain; Department of Statistics and Operations Research, University of Valencia, Burjassot, Spain.
Ming-Huei ChenPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA.
Daniel L McCartneyCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Alexander TeumerDepartment SHIP/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland.
Jenny van DongenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany.
Dylan AïssiUniv. Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Molecular Epidemiology of Vascular and Brain Disorders, Bordeaux, France.
Brenton R SwensonCardiovascular Health Research Unit, School of Public Health, University of Washington, Seattle, Washington, USA.
Jie YaoPediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Jian HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Yujing XiaDepartment of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, King's College London, London, United Kingdom.
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Ricardo CosteiraDepartment of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, King's College London, London, United Kingdom.
Eco J C de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Dre'Von A DobsonPathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Paul ElliottDepartment of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom; UK Dementia Research Institute, Imperial College London, London, United Kingdom; British Heart Foundation Centre for Research Excellence, Imperial College London, London, United Kingdom.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Xiuqing GuoPediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Sarah E HarrisLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
Jennifer E HuffmanMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Yongmei LiuMedicine, Cardiology, Duke Molecular Physiology Institute, Durham, North Carolina, USA.
Stefan LorkowskiInstitute of Nutritional Sciences, Friedrich Schiller University Jena, Jena, Germany; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany.
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.
Matthias NauckDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Scott M RatliffDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Maria Sabater-LlealGenomics of Complex Disease Unit, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Department of Medicine, Cardiovascular Medicine Unit, Karolinska Institutet, Stockholm, Sweden.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, King's College London, London, United Kingdom.
Pierre SuchonCenter for CardioVascular and Nutrition research (C2VN), INSERM 1263, INRAE 1260, Hematology Laboratory, La Timone University Hospital of Marseille, Aix-Marseille University, Marseille, France.
Kent D TaylorPediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Florian ThibordPopulation Sciences Branch, National Heart, Lung, and Blood Institute, Framingham, Massachusetts, USA.
David-Alexandre TrégouëtUniv. Bordeaux, INSERM, Bordeaux Population Health Research Center, UMR 1219, Molecular Epidemiology of Vascular and Brain Disorders, Bordeaux, France.
Kerri L WigginsDepartment of Medicine, Division of General Internal Medicine, University of Washington, Seattle, Washington, USA.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, St Thomas Hospital Campus, King's College London, London, United Kingdom.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Shelley A ColePopulation Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Simon R CoxLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
Abbas DehghanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
Andreas GreinacherInstitute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Karin HaackPopulation Health Program, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Pierre-Emmanuel MorangeCardiovascular and Nutrition Reserach Center (C2VN), INSERM, INRAE, Aix-Marseille University, Marseille, France.
Jerome I RotterPediatrics, Genomic Outcomes, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Nona SotoodehniaDepartment of Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA.
Maria Tellez-PlazaDepartment of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institutes, Madrid, Spain.
Ana Navas-AcienDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Andrew D JohnsonPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Framingham, Massachusetts, USA.
Myriam FornageHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Nicholas L SmithDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, Washington, USA; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, Washington, USA.
Alisa S WolbergPathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA. Electronic address: paul.s.devries@uth.tmc.edu.
The University of Texas Health Science Center at Houston · USSt Thomas' Hospital · GBUCLA Medical Center · USUniversity of Michigan · USVrije Universiteit Amsterdam · NLNational Heart Lung and Blood Institute · USUniversitätsmedizin Greifswald · DEUniversity of Washington · USEdinburgh Cancer Research · GBHeidelberg University · DEImperial College London · GBInserm · FRNHS Lothian · GBTexas Biomedical Research Institute · USUniversité de Bordeaux · FRUniversity of North Carolina at Chapel Hill · USBritish Heart Foundation · GBColumbia University · USDuke Medical Center · USFriedrich Schiller University Jena · DE
Funding
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MUsing genomics and functional biology to understand fibrinogen and its effect on thrombotic and atherosclerotic outcomesR01HL141291 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Alanna C Morrison, Alisa S. Wolberg · 2019 to 2026
$4.6MFibrinogen and Factor XIII in Venous ThrombosisR01HL126974 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alisa S. Wolberg · 2016 to 2026
$4.4MPopulation genomic variation, functional biology, and the risk of venous thrombosisR01HL134894 · NHLBI · UNIVERSITY OF WASHINGTON · PI LOWENSTEIN, CHARLES J, SMITH, NICHOLAS L · 2017 to 2020
$2.9MBiotechnology and Biological Sciences Research Council BB/S020845/1Medical Research Council MR/R023484/1NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL126974NHLBI NIH HHS R01 HL134894NHLBI NIH HHS R01 HL141291
Abstract
backgroundFibrinogen plays an essential role in blood coagulation and inflammation. Circulating fibrinogen levels may be determined based on interindividual differences in DNA methylation at cytosine-phosphate-guanine (CpG) sites and vice versa.
objectivesTo perform an EWAS to examine an association between blood DNA methylation levels and circulating fibrinogen levels to better understand its biological and pathophysiological actions.
methodsWe performed an epigenome-wide association study of circulating fibrinogen levels in 18 037 White, Black, American Indian, and Hispanic participants, representing 14 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Circulating leukocyte DNA methylation was measured using the Illumina 450K array in 12 904 participants and using the EPIC array in 5133 participants. In each study, an epigenome-wide association study of fibrinogen was performed using linear mixed models adjusted for potential confounders. Study-specific results were combined using array-specific meta-analysis, followed by cross-replication of epigenome-wide significant associations. We compared models with and without CRP adjustment to examine the role of inflammation.
resultsWe identified 208 and 87 significant CpG sites associated with fibrinogen levels from the 450K (p < 1.03 × 10
conclusionWe identified 83 CpG sites associated with circulating fibrinogen levels. These associations are partially driven by inflammatory pathways shared by both fibrinogen and CRP.
Indexed as
DNA MethylationEpigenesis, GeneticCpG IslandsFibrinogenGenetic LociGenome-Wide Association StudyHumansInflammationFibrinogenDNA methylationepigenome-wide association studyfibrinogeninflammationMendelian randomization
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