Evidence map›Paper›PMID 36716581›Full record

ReviewTicks and tick-borne diseases2023

Putative target sites in synganglion for novel ixodid tick control strategies.

Jéssica Waldman, Guilherme Marcondes Klafke, Lucas Tirloni, Carlos Logullo, Itabajara da Silva Vaz

Abstract readReview
In one paragraph

Review in Ticks and tick-borne diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Field evaluation ofVeterinary world · 2026
    Article
  2. Acaricidal Effect of Essential Oils in the Control ofPathogens (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Review
  5. Evolution of tick vaccinology.Parasitology · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jéssica WaldmanCentro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Guilherme Marcondes KlafkeInstituto de Pesquisas Veterinárias Desidério Finamor - Centro de Pesquisa em Saúde Animal, Secretaria da Agricultura, Pecuária e Desenvolvimento Rural, Eldorado do Sul, RS, Brazil; Instituto Nacional de Ciência e Tecnologia - Entomologia Molecular, Rio de Janeiro, RJ, Brazil.
Lucas TirloniLaboratory of Bacteriology, Tick-Pathogen Transmission Unit, National Institute of Allergy and Infectious Diseases, Hamilton, MT, USA.
Carlos LogulloInstituto Nacional de Ciência e Tecnologia - Entomologia Molecular, Rio de Janeiro, RJ, Brazil; Laboratório de Bioquímica de Artrópodes Hematófagos, IBqM, Universidade Federal do Rio de Janeiro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Itabajara da Silva VazCentro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Instituto Nacional de Ciência e Tecnologia - Entomologia Molecular, Rio de Janeiro, RJ, Brazil; Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: itabajara.vaz@ufrgs.br.

Funding

Tick saliva and its importance for tick feeding and pathogen transmissionZIAAI001337 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TIRLONI, LUCAS · 2021 to 2025
$8.5M
Intramural NIH HHS Z99 AI999999Intramural NIH HHS ZIA AI001337
6 · The paper itself

Abstract

Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to animals and humans result in important economic and public health burden, it is essential to develop new strategies for their control (i.e., novel chemical compounds, vaccines, biological control). The synganglion is the tick central nervous system and it is responsible for synthesizing and releasing signaling molecules with different physiological functions. Synganglion proteins are the targets of the majority of available acaricides. In this review we provide an overview of the mode-of-action and resistance mechanisms against neurotoxic acaricides in ticks, as well as putative target sites in synganglion, as a supporting tool to identify new target proteins and to develop new strategies for tick control.

Indexed as

AcaricidesCattle DiseasesIxodidaeRhipicephalusTick InfestationsVaccinesAnimalsCattleHumansTick ControlAcaricidesVaccinesAcaricideControlRhipicephalus microplus

Identifiers

PMID36716581
PMCPMC10033424

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.