Evidence map›Paper›PMID 36715782›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Clinical relevance of macroglossia to disease progression in ventilation dependent patients with advanced ALS.

Chiharu Matsuda, Toshio Shimizu, Yuki Nakayama, Michiko Haraguchi, Chiyoko Hakuta, Rena Hidaka, Akira Nishiyama, Takaya Numayama

Abstract read
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chiharu MatsudaUnit for Intractable Disease Nursing Care, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9209-6094
Toshio ShimizuDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo, 183-0042, Japan. toshio_shimizu@tmhp.jp.ORCID http://orcid.org/0000-0002-3828-9669
Yuki NakayamaUnit for Intractable Disease Nursing Care, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID http://orcid.org/0000-0001-8620-612X
Michiko HaraguchiUnit for Intractable Disease Nursing Care, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Chiyoko HakutaDepartment of Oral Health Sciences for Community Welfare, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Rena HidakaDepartment of Oral Health Sciences for Community Welfare, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4998-6275
Akira NishiyamaDepartment of Orofacial Pain Management, Tokyo Medical and Dental University, Tokyo, Japan.
Takaya NumayamaDepartment of Neurology, Sayama Neurological Hospital, Saitama, Japan.ORCID http://orcid.org/0000-0002-3590-0653
Tokyo Medical and Dental University · JPTokyo Metropolitan Institute of Medical Science · JPTokyo Metropolitan Neurological Hospital · JP

Funding

Japan Society for the Promotion of Science 16K12054Japan Society for the Promotion of Science 19K10896
6 · The paper itself

Abstract

backgroundMacroglossia is one of the clinical signs that emerges in patients with amyotrophic lateral sclerosis (ALS) who are undergoing invasive ventilation.

objectiveWe aimed to investigate the relationship between the progression of macroglossia and the clinical characteristics during the advanced stages of ALS.

methodsForty-one patients with ALS using invasive ventilation with tracheostomy were prospectively followed over a 3-year period. We evaluated the prevalence of macroglossia, motor disabilities including oral function, communication ability (communication stage I to V) as a marker of disease progression, and nutritional factors. We analyzed the potential factors affecting the progression of macroglossia using a multivariate logistic analysis.

resultsThe number of patients with macroglossia was increased during the follow-up (from 24.4 to 53.7%), while the communication stage progressed from 2.6 in average (SD 1.7) to 3.5 (1.4). During the study, body weight increased, while energy intake decreased, suggesting progressive hypometabolism. Eight patients had newly developed macroglossia during the study and showed greater progression of communication impairment than those without macroglossia. Multivariate logistic regression analysis showed that communication impairment was a factor associated with macroglossia.

conclusionMacroglossia in advanced ALS with invasive ventilation is associated with disease progression.

Indexed as

Amyotrophic Lateral SclerosisMacroglossiaClinical RelevanceDisease ProgressionHumansAmyotrophic lateral sclerosisBody mass indexCommunication impairmentInvasive ventilationMacroglossia

Identifiers

PMID36715782
OpenAlexW4318482262

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.