Evidence map›Paper›PMID 36715780›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

Neuronal intranuclear inclusion disease mimicking progressive supranuclear palsy.

Min Tian, Yinlian Han, Yiqing Bi, Bohan Zhang, Ruonan Duan, Chengyuan Song, Yiming Liu

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Min TianDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, China.
Yinlian HanDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, China.
Yiqing BiDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, China.
Bohan ZhangDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, China.
Ruonan DuanDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, China.
Chengyuan SongDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, China.
Yiming LiuDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, China. liuym@sdu.edu.cn.ORCID http://orcid.org/0000-0001-7200-7197
Qilu Hospital of Shandong University · CN

Funding

National Natural Science Foundation of China 82171245
6 · The paper itself

Abstract

backgroundGiven the variable nature of clinical manifestations, neuronal intranuclear inclusion disease (NIID) is regarded as a heterogeneous disease which is challenging to diagnose early. To the present, progressive supranuclear palsy (PSP)-like symptoms have never been listed in the performance of NIID. CASE PRESENTATION: A 58-year-old man presented with progressive Parkinsonism and postural instability for 3 years. Initially, he was considered as probable PSP due to vertical supranuclear gaze palsy, postural instability, and hummingbird sign. No high-intensity signal on diffusion-weighted imaging (DWI) was revealed. Eventually, the diagnosis was revised to NIID by Notch 2 N-terminal like C (NOTCH2NLC) GGC repeat expansions and skin biopsy showing intranuclear eosinophilic inclusions in the vesicles and ductal epithelial cells of sweat glands.

conclusionEven if the typical high-intensity along the corticomedullary junction (CMJ) on DWI is lacking, clinicians should be alert to the possibility of NIID when PSP-like symptoms develop. This case report offers new features of NIID and expands its clinical spectrum.

Indexed as

Movement DisordersNeurodegenerative DiseasesSupranuclear Palsy, ProgressiveDiffusion Magnetic Resonance ImagingHumansIntranuclear Inclusion BodiesMaleMiddle AgedDifferential diagnosisDiffusion-weighted imagingNeuronal intranuclear inclusion diseaseProgressive supranuclear palsy-like symptoms

Identifiers

PMID36715780
OpenAlexW4318457251

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.