Evidence map›Paper›PMID 36715687›Full record

ArticleeLife2023

An IS-mediated, RecA-dependent, bet-hedging strategy in

Lillian C Lowrey, Leslie A Kent, Bridgett M Rios, Angelica B Ocasio, Peggy A Cotter

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
7.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Cell wall remodeling-dependent morphotype switch inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Exploring phage-host interactions inMicrobiology spectrum · 2025
    Article
  8. Colony morphotype variation inJournal of bacteriology · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lillian C LowreyDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0001-7602-033X
Leslie A KentDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0003-3195-0247
Bridgett M RiosDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Angelica B OcasioDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Peggy A CotterDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0003-3726-3990
University of North Carolina at Chapel Hill · US

Funding

UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Contact-dependent signaling and DNA transposition in BurkholderiaR35GM136533 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COTTER, PEGGY A · 2020 to 2024
$1.9M
Contact-Dependent Signaling in BurkholderiaR01GM121110 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COTTER, PEGGY A · 2016 to 2019
$1.2M
NICHD NIH HHS P50 HD103573NIGMS NIH HHS R01 GM121110NIGMS NIH HHS R35 GM136533NIH HHS R01 GM121110NIH HHS R35 GM136533NINDS NIH HHS P30 NS045892
6 · The paper itself

Abstract

Adaptation to fluctuating environmental conditions is difficult to achieve. Phase variation mechanisms can overcome this difficulty by altering genomic architecture in a subset of individuals, creating a phenotypically heterogeneous population with subpopulations optimized to persist when conditions change, or are encountered, suddenly. We have identified a phase variation system in

Indexed as

BurkholderiaDNA Transposable ElementsBiofilmsGenomicsHumansDNA Transposable Elementsbet hedgingBurkholderia thailandensisgenetic heterogeneitygeneticsgenomicshomologous recombinationinfectious diseasemicrobiologyphase variationphenotypic heterogeneity

Identifiers

PMID36715687
PMCPMC9946442
OpenAlexW4318483595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.