Evidence map›Paper›PMID 36715623›Full record

Trial reportJournal of the National Cancer Institute2023

Detection of colon cancer recurrences during follow-up care by general practitioners vs surgeons.

Julien A M Vos, Edanur Sert, Wim B Busschers, Laura A M Duineveld, Thijs Wieldraaijer, Jan Wind, Sandra C Donkervoort, Marc J P M Govaert, Frédérique H Beverdam, Anke B Smits and 5 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the National Cancer Institute, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Julien A M VosDepartment of General Practice, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-3383-8171
Edanur SertDepartment of General Practice, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.
Wim B BusschersDepartment of General Practice, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.
Laura A M DuineveldDepartment of General Practice, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.
Thijs WieldraaijerDepartment of General Practice, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.
Jan WindDepartment of General Practice, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.
Sandra C DonkervoortDepartment of Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands.
Marc J P M GovaertDepartment of Surgery, Dijklander Hospital, Hoorn, the Netherlands.
Frédérique H BeverdamDepartment of Surgery, Franciscus Gasthuis & Vlietland Hospital, Schiedam, the Netherlands.
Anke B SmitsDepartment of Surgery, St. Antonius Hospital, Nieuwegein, the Netherlands.
Willem A BemelmanDepartment of Surgery, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.
Gijsbert HeuffDepartment of Surgery, Spaarne Gasthuis, Hoofddorp, the Netherlands.
Henk C P M van WeertDepartment of General Practice, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.
Kristel M van AsseltDepartment of General Practice, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.
I CARE study Group
Amsterdam University Medical Centers · NLGGD Amsterdam · NLOLVG · NLReinier de Graaf Hospital · NLSint Franciscus Gasthuis · NLSpaarne Ziekenhuis · NLSt. Antonius Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the I CARE study, colon cancer patients were randomly assigned to receive follow-up care from either a general practitioner (GP) or a surgeon. Here, we address a secondary outcome, namely, detection of recurrences and effect on time to detection of transferring care from surgeon to GP.

methodsPattern, stage, and treatment of recurrences were described after 3 years. Time to event was defined as date of surgery, until date of recurrence or last follow-up, with death as competing event. Effects on time to recurrence and death were estimated as hazard ratios (HRs) using Cox regression. Restricted mean survival times were estimated.

resultsOf 303 patients, 141 were randomly assigned to the GP and 162 to the surgeon. Patients were male (67%) with a mean age of 68.0 (8.4) years. During follow-up, 46 recurrences were detected; 18 (13%) in the GP vs 28 (17%) in the surgeon group. Most recurrences were detected via abnormal follow-up tests (74%) and treated with curative intent (59%). Hazard ratio for recurrence was 0.75 (95% confidence interval [CI] = 0.41 to 1.36) in GP vs surgeon group. Patients in the GP group remained in the disease-free state slightly longer (2.76 vs 2.71 years). Of the patients, 38 died during follow-up; 15 (11%) in the GP vs 23 (14%) in the surgeon group. Of these, 21 (55%) deaths were related to colon cancer. There were no differences in overall deaths between the groups (HR = 0.76, 95% CI = 0.39 to 1.46).

conclusionFollow-up provided by GPs vs surgeons leads to similar detection of recurrences. Also, no differences in mortality were found.

Indexed as

Colonic NeoplasmsGeneral PractitionersSurgeonsAftercareAgedFemaleFollow-Up StudiesHumansMaleNeoplasm Recurrence, Local

Identifiers

PMID36715623
PMCPMC10165489
OpenAlexW4318542995

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.