ArticleJournal of experimental botany2023
A novel mutant allele of AtCNGC15 reveals a dual function of nuclear calcium release in the root meristem.
Article in Journal of experimental botany, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- CNGCs in Marchantia paleacea uncouple arbuscular mycorrhizal symbiosis and rhizoid development.The New phytologist · 2026Article
- Phylogenomic and super-pangenome analyses unveil the genetic landscape of tomato evolution and domestication.Plant biotechnology journal · 2025Article
- Symbiotic nitrogen fixation: a launchpad for investigating old and new challenges.Journal of experimental botany · 2025Article
- Genome-wide identification of cyclic nucleotide-gated channel gene family inFrontiers in plant science · 2025Article
- Modification of xylan in secondary walls alters cell wall biosynthesis and wood formation programs and improves saccharification.Plant biotechnology journal · 2025Article
- Hydraulic-physiological coordination predicts drought recovery: evidence from ten dry-hot valley species.Frontiers in plant science · 2025Article
- Plant NLR immunity activation and execution: a biochemical perspective.Open biology · 2024Review
- Finding Balance in Adversity: Nitrate Signaling as the Key to Plant Growth, Resilience, and Stress Response.International journal of molecular sciences · 2023Review
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Calcium release to the nucleoplasm of root meristem cells was demonstrated to modulate root development. The calcium channel encoded by cyclic nucleotide-gated channel (CNGC) 15 localizes at the nuclear envelope in young Arabidopsis seedlings. In contrast, at later stages of root growth, overexpression analysis showed that AtCNGC15 can relocalize to the plasma membrane to mediate primary nitrate-induced gene expression. This raises the question as to whether nuclear localized AtCNGC15 is required for root apical meristem development in young Arabidopsis seedlings, and whether nitrate signalling occurs independently of nuclear localized AtCNGC15 at this developmental stage. In this study, we characterize a novel mutant allele of AtCNGC15 and demonstrate that the mutation of a highly conserved aspartic acid in the C-linker domain is sufficient to impair the gating of AtCNCG15. We demonstrate that AtCNGC15 mediates the nuclear calcium release that modulates root apical meristem development and nitrate-induced LBD39 expression. We also show that, in the presence of nitrate, the relocalization of AtCNGC15 at the plasma membrane occurs specifically in the columella cells. Our results further suggest that the induction of LBD37, LBD38, and LBD39 in the presence of nitrate is modulated by different inputs of cytoplasmic or nuclear calcium release.
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