Evidence map›Paper›PMID 36715213›Full record

ArticleThe EMBO journal2023

The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner.

Ivy K N Chiang, Matthew S Graus, Nils Kirschnick, Tara Davidson, Winnie Luu, Richard Harwood, Keyi Jiang, Bitong Li, Yew Yan Wong, Mehdi Moustaqil and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. SOX on tumors, a comfort or a constraint?Cell death discovery · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 4 countries.

Ivy K N ChiangThe Centenary Institute, David Richmond Program for Cardio-Vascular Research: Gene Regulation and Editing, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Matthew S GrausThe Centenary Institute, David Richmond Program for Cardio-Vascular Research: Gene Regulation and Editing, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Nils KirschnickEuropean Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany.
Tara DavidsonThe Centenary Institute, David Richmond Program for Cardio-Vascular Research: Gene Regulation and Editing, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Winnie LuuThe Centenary Institute, David Richmond Program for Cardio-Vascular Research: Gene Regulation and Editing, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Richard HarwoodSydney Microscopy and Microanalysis, University of Sydney, Sydney, NSW, Australia.
Keyi JiangThe Centenary Institute, David Richmond Program for Cardio-Vascular Research: Gene Regulation and Editing, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Bitong LiThe Centenary Institute, David Richmond Program for Cardio-Vascular Research: Gene Regulation and Editing, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.ORCID 0000-0003-2202-8218
Yew Yan WongThe Genome Imaging Center, The Centenary Institute, Sydney, NSW, Australia.ORCID 0000-0001-6557-4492
Mehdi MoustaqilEMBL Australia Node in Single Molecule Science, and School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Emmanuelle LesieurInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia.
Renae SkoczylasInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, Australia.
Valerie KouskoffDivision of Developmental Biology & Medicine, The University of Manchester, Manchester, UK.
Jan KazenwadelCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.ORCID 0000-0001-6216-3444
Luis Arriola-MartinezCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.
Emma SiereckiEMBL Australia Node in Single Molecule Science, and School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0001-9970-868X
Yann GambinEMBL Australia Node in Single Molecule Science, and School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Kari AlitaloWihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-7331-0902
Friedmann KieferEuropean Institute for Molecular Imaging (EIMI), University of Münster, Münster, Germany.
Natasha L HarveyCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.
Mathias FrancoisThe Centenary Institute, David Richmond Program for Cardio-Vascular Research: Gene Regulation and Editing, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.ORCID 0000-0002-9846-6882
The University of Sydney · AUSouth Australia Pathology · AUUNSW Sydney · AUThe University of Queensland · AUUniversity of Münster · DECentenary Institute · AUUniversity of Helsinki · FIUniversity of Manchester · GB

Funding

Medical Research Council MR/T000384/1
6 · The paper itself

Abstract

Despite a growing catalog of secreted factors critical for lymphatic network assembly, little is known about the mechanisms that modulate the expression level of these molecular cues in blood vascular endothelial cells (BECs). Here, we show that a BEC-specific transcription factor, SOX7, plays a crucial role in a non-cell-autonomous manner by modulating the transcription of angiocrine signals to pattern lymphatic vessels. While SOX7 is not expressed in lymphatic endothelial cells (LECs), the conditional loss of SOX7 function in mouse embryos causes a dysmorphic dermal lymphatic phenotype. We identify novel distant regulatory regions in mice and humans that contribute to directly repressing the transcription of a major lymphangiogenic growth factor (Vegfc) in a SOX7-dependent manner. Further, we show that SOX7 directly binds HEY1, a canonical repressor of the Notch pathway, suggesting that transcriptional repression may also be modulated by the recruitment of this protein partner at Vegfc genomic regulatory regions. Our work unveils a role for SOX7 in modulating downstream signaling events crucial for lymphatic patterning, at least in part via the transcriptional repression of VEGFC levels in the blood vascular endothelium.

Indexed as

Endothelial CellsLymphatic VesselsAnimalsEndothelium, VascularGene Expression RegulationHumansLymphangiogenesisMiceSOXF Transcription FactorsTranscription FactorsSOX7 protein, humanSox7 protein, mouseSOXF Transcription FactorsTranscription Factorsblood vesselsgene regulationlymphatic endothelial cellSOX transcription factorVEGFC

Identifiers

PMID36715213
PMCPMC9975944
OpenAlexW4318477849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.