Evidence map›Paper›PMID 36715156›Full record

ArticleMedical mycology2023

Genomic description of human clinical Aspergillus fumigatus isolates, California, 2020.

Elizabeth Misas, John Z Deng, Jeremy A W Gold, Lalitha Gade, Natalie S Nunnally, Ourania Georgacopoulos, Meghan Bentz, Elizabeth L Berkow, Anastasia P Litvintseva, Tom M Chiller and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical mycology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Elizabeth MisasMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0001-6243-7716
John Z DengDavid Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Jeremy A W GoldMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Lalitha GadeMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Natalie S NunnallyMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Ourania GeorgacopoulosMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Meghan BentzMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Elizabeth L BerkowMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Anastasia P LitvintsevaMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Tom M ChillerMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jeffrey D KlausnerDepartments of Population and Public Health Sciences and Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Nancy A ChowMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Centers for Disease Control and Prevention · USUniversity of California, Los Angeles · USUniversity of Southern California · US

Funding

Oak Ridge Institute for Science and Education
6 · The paper itself

Abstract

Aspergillus fumigatus, an environmental mold, causes life-threatening infections. Studies on the phylogenetic structure of human clinical A. fumigatus isolates are limited. Here, we performed whole genome sequencing of 24 A. fumigatus isolates collected from 18 patients in U.S. healthcare facilities in California. Single-nucleotide polymorphism (SNP) differences between patient isolates ranged from 187 to 70 829 SNPs. For five patients with multiple isolates, we calculated the within-host diversities. Three patients had a within-host diversity that ranged from 4 to 10 SNPs and two patients ranged from 2 to 16 977 SNPs. Findings revealed highly diverse A. fumigatus strains among patients and two patterns of diversity for isolates that come from the same patient, low and extremely high diversity.

Indexed as

AspergillosisAspergillus fumigatusAntifungal AgentsCaliforniaGenomicsHumansPhylogenyAntifungal AgentsaspergillosisAspergillus fumigatusgenomicswhole genome sequencing

Identifiers

PMID36715156
PMCPMC9945844
OpenAlexW4318478192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.