Evidence map›Paper›PMID 36714682›Full record

ArticleJCPP advances2022

Bipolar spectrum disorders are associated with increased gray matter volume in the medial orbitofrontal cortex and nucleus accumbens.

Katherine S F Damme, Lauren B Alloy, Nicholas J Kelley, Ann Carroll, Christina B Young, Jason Chein, Tommy H Ng, Madison K Titone, Corinne P Bart, Robin Nusslock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCPP advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Sex differences in anhedonia in bipolar depression: a resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Katherine S F DammeDepartment of Psychology, Northwestern University, Evanston, Illinois, USA.ORCID 0000-0003-4260-1528
Lauren B AlloyDepartment of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Nicholas J KelleyDepartment of Psychology, Northwestern University, Evanston, Illinois, USA.
Ann CarrollDepartment of Psychology, Northwestern University, Evanston, Illinois, USA.
Christina B YoungDepartment of Psychology, Northwestern University, Evanston, Illinois, USA.
Jason CheinDepartment of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Tommy H NgDepartment of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Madison K TitoneDepartment of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Corinne P BartDepartment of Psychology, Temple University, Philadelphia, Pennsylvania, USA.
Robin NusslockDepartment of Psychology, Northwestern University, Evanston, Illinois, USA.
Northwestern University · USTemple University · US

Funding

Risk for Bipolar Disorder: Reward-related Brain Function & Social RhythmsR01MH077908 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2007 to 2017
$5.7M
Integrated Reward-Circadian Rhythm Model of First Onset of Bipolar Spectrum Disorders in Adolescence SupplementR01MH126911 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH, NUSSLOCK, ROBIN · 2021 to 2025
$3.8M
Symptom Dimension of Threat- and Reward-Related NeurocircuitryR01MH100117 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y, CRASKE, MICHELLE G · 2014 to 2018
$3.8M
Social and Circadian Rhythms, Reward Sensitivity, and Risk for Bipolar DisorderR01MH102310 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2014 to 2017
$1.6M
Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of PsychopathologyT32MH126368 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHANKMAN, STEWART AARON, WAKSCHLAG, LAUREN S · 2021 to 2025
$1.4M
NIMH NIH HHS R01 MH077908NIMH NIH HHS R01 MH100117NIMH NIH HHS R01 MH102310NIMH NIH HHS R01 MH126911NIMH NIH HHS T32 MH126368
6 · The paper itself

Abstract

Objective: Elevated sensitivity to rewards prospectively predicts Bipolar Spectrum Disorder (BSD) onset; however, it is unclear whether volumetric abnormalities also reflect BSD risk. BSDs emerge when critical neurodevelopment in frontal and striatal regions occurs in sex-specific ways. The current paper examined the volume of frontal and striatal brain regions in both individuals with and at risk for a BSD with exploratory analyses examining sex-specificity. Methods: One hundred fourteen medication-free individuals ages 18-27 at low-risk for BSD (moderate-reward sensitivity; Results: The BSD group had enlarged frontostriatal volumes (mOFC, NAcc) compared to low individuals ( Conclusions: An enlarged frontostriatal volume (averaged mOFC, NAcc) is associated with the presence of a BSD, while subvolumes (mOFC vs. NAcc) showed unique patterning in relation to risk. We report preliminary evidence that sex moderates frontostriatal volume in BSD, highlighting the need for larger longitudinal risk studies examining the role of sex-specific neurodevelopmental trajectories in emerging BSDs.

Indexed as

bipolar spectrum disorderfrontostriatalgray matter volumemalerewardrisk

Identifiers

PMID36714682
PMCPMC9879263
OpenAlexW4221120987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.