Evidence map›Paper›PMID 36714634›Full record

ArticleFrontiers in bioengineering and biotechnology2022

A poly (glycerol-sebacate-acrylate) nanosphere enhanced injectable hydrogel for wound treatment.

Jiajia Luo, Fenglei Sun, Pinhua Rao, Tonghe Zhu, Yonghang Liu, Juan Du, Sihao Chen, Xiangyun Jin, Jiale Jin, Yi Chai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jiajia LuoSchool of Chemistry and Chemical Engineering, Institute for Frontier Medical Technology, Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-coding RNA, Shanghai University of Engineering Science, Shanghai, China.
Fenglei SunDepartment of Neurosurgery, Weifang People's Hospital, Weifang, Shandong, China.
Pinhua RaoSchool of Chemistry and Chemical Engineering, Institute for Frontier Medical Technology, Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-coding RNA, Shanghai University of Engineering Science, Shanghai, China.
Tonghe ZhuSchool of Chemistry and Chemical Engineering, Institute for Frontier Medical Technology, Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-coding RNA, Shanghai University of Engineering Science, Shanghai, China.
Yonghang LiuSchool of Chemistry and Chemical Engineering, Institute for Frontier Medical Technology, Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-coding RNA, Shanghai University of Engineering Science, Shanghai, China.
Juan DuSchool of Chemistry and Chemical Engineering, Institute for Frontier Medical Technology, Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-coding RNA, Shanghai University of Engineering Science, Shanghai, China.
Sihao ChenSchool of Chemistry and Chemical Engineering, Institute for Frontier Medical Technology, Shanghai Engineering Research Center of Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Non-coding RNA, Shanghai University of Engineering Science, Shanghai, China.
Xiangyun JinDepartment of Orthopaedics, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jiale JinSpine Lab, Department of Orthopaedic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Yi ChaiDepartment of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shanghai University · CNRenji Hospital · CNFirst Affiliated Hospital Zhejiang University · CNWeifang People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound repair remains a huge clinical challenge, which can cause bleeding, infection, and patient death. In our current research, a bioactive, injectable, multifunctional composite hydrogel doped with nanospheres was prepared with antibacterial and angiogenesis-promoting functions for the treatment of wounds. Amino groups in ε-polylysine (ε-EPL) undergo dynamic Schiff base reaction cross-linking with oxidized hyaluronic acid (OHA), and F127 exhibits unique temperature sensitivity to form an injectable thermosensitive hydrogel (FHE10), which can form a hydrogel to cover the wound at body temperature. Nanospheres (PNs) prepared using poly (glyceryl-sebacate-acrylate) (PGSA) were loaded into hydrogels (FHE10) for promoting wound repair. The prepared FHE10 exhibited rapid gelation, good injectable abilities, and showed resistance to the flourish of

Indexed as

antibacterialinjectable hydrogelpoly (glycerol-sebacate-acrylate) nanospherevascularizationwound treatment

Identifiers

PMID36714634
PMCPMC9877222
OpenAlexW4315782243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.