Evidence map›Paper›PMID 36714580›Full record

ArticleFrontiers in endocrinology2022

Comprehensive analysis of the effect of Hashimoto's thyroiditis on the diagnostic efficacy of preoperative ultrasonography on cervical lymph node lesions in papillary thyroid cancer.

Hai-Long Tan, AdolphusOsei Nyarko, Sai-Li Duan, Ya-Xin Zhao, Pei Chen, Qiao He, Zhe-Jia Zhang, Shi Chang, Peng Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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  4. Review: Detection of Cancer Biomarkers from a Clinical Perspective.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hai-Long TanDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, China.
AdolphusOsei NyarkoDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, China.
Sai-Li DuanDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, China.
Ya-Xin ZhaoDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, China.
Pei ChenDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, China.
Qiao HeDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, China.
Zhe-Jia ZhangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, China.
Shi ChangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, China.
Peng HuangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, China.
Xiangya Hospital Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Hashimoto's thyroiditis often leads to reactive hyperplasia of the central compartment lymph nodes in papillary thyroid carcinoma (PTC) patients. However, the effect and clinical significance of Hashimoto's thyroiditis (HT) on ultrasonography evaluation for cervical lymph node (LN) lesions remain unknown. This study aims to investigate the effect of Hashimoto's thyroiditis on the diagnostic efficacy of preoperative ultrasonography on cervical lymph node lesions in PTC patients. Patients and methods: This study consecutively enrolled 1,874 PTC patients who underwent total thyroidectomy and radical cervical lymph node dissection between January 2010 and December 2021. Eligible patients were categorized as with HT and without HT. The diagnostic performance of preoperative ultrasonography for cervical LN lesions (including central LNs and lateral LNs) was evaluated between PTC patients with HT and those without HT, respectively. Results: Among the 1,874 PTC patients, 790 (42.1%) had central cN+ and 1,610 (85.9%) had lateral cN+. Compared with PTC patients without HT, the preoperative US for central LNs displays a higher false-positive rate (27.9% vs. 12.2%, Conclusion: HT will interfere with the preoperative US evaluation for central LNs and increase the incidence of the absence of fatty hilum in central benign LNs. When PTC patients have concomitant HT, clinicians should thoroughly evaluate the central LNs, thereby decreasing the incidence of misdiagnosis and unnecessary surgery.

Indexed as

Carcinoma, PapillaryHashimoto DiseaseThyroid NeoplasmsHumansLymphatic MetastasisLymph NodesRetrospective StudiesThyroid Cancer, PapillaryUltrasonographydiagnostic efficacyHashimoto’s thyroiditislymph node metastasispapillary thyroid carcinomaultrasonography

Identifiers

PMID36714580
PMCPMC9877506
OpenAlexW4315641196

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.