Evidence map›Paper›PMID 36714342›Full record

ArticleChinese journal of cancer research = Chung-kuo yen cheng yen chiu2022

A multi-center, open-label, randomized, parallel-controlled phase II study comparing pharmacokinetic, pharmacodynamics and safety of ripertamab (SCT400) to rituximab (MabThera

Xiaohong Han, Mingzhi Zhang, Huaqing Wang, Qingyuan Zhang, Wei Li, Miaowang Hao, Yuhuan Gao, Jie Jin, Hanyun Ren, Yun Tang and 8 more

Open access · diamondAbstract read
In one paragraph

Article in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Observational
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

Xiaohong HanClinical Pharmacology Research Center, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Mingzhi ZhangDepartment of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Huaqing WangDepartment of Medical Oncology, Tianjin People's Hospital, Tianjin 300121, China.
Qingyuan ZhangDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China.
Wei LiOncology Department of Cancer Center, the First Hospital of Jilin University, Changchun 130021, China.
Miaowang HaoDepartment of Hematology, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China.
Yuhuan GaoDepartment of Hematology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
Jie JinDepartment of Hematology, the First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China.
Hanyun RenDepartment of Hematology, Peking University First Hospital, Beijing 100034, China.
Yun TangDepartment of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiaonan HongDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Xiaoyan KeDepartment of Hematology, Peking University Third Hospital, Beijing 100191, China.
Hang SuDepartment of Lymphoma, the Fifth Medical Center of PLA General Hospital, Beijing 100071, China.
Lin GuiDepartment of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing 100021, China.
Jianmin LuoDepartment of Hematology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Liangzhi XieBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Wenlin GaiBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Yuankai ShiDepartment of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing 100021, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNSinocelltech Group (China) · CNFirst Affiliated Hospital of Zhengzhou University · CNFudan University Shanghai Cancer Center · CNHarbin Medical University · CNPeking Union Medical College Hospital · CNPeking University · CNPeking University Third Hospital · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This multi-center, open-label, randomized, parallel-controlled phase II study aimed to compare the pharmacokinetics (PK), pharmacodynamics (PD) and safety profile of ripertamab (SCT400), a recombinant anti-CD20 monoclonal antibody, to rituximab (MabThera Methods: Patients with CD20-positive B-cell NHL who achieved complete remission or unconfirmed complete remission after standard treatment were randomly assigned at a 1:1 ratio to receive a single dose of ripertamab (375 mg/m Results: From December 30, 2014 to November 24, 2015, a total of 84 patients were randomized (ripertamab, n=42; rituximab, n=42) and the PK analysis was performed on 76 patients (ripertamab, n=38; rituximab, n=38). The geometric mean ratios of ripertamab/rituximab for AUC Conclusions: In this study, the PK, PD, immunogenicity, and safety profile of ripertamab (SCT400) were similar to rituximab (MabThera

Indexed as

Anti-CD20 monoclonal antibodynon-Hodgkin lymphomapharmacokineticsripertamabrituximabsafety

Identifiers

PMID36714342
PMCPMC9829503
OpenAlexW4315698723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.