Evidence map›Paper›PMID 36714262›Full record

ArticleFrontiers in molecular biosciences2023

A new and efficient procedure to load bioactive molecules within the human heavy-chain ferritin nanocage.

Rosanna Lucignano, Ilaria Stanzione, Giarita Ferraro, Rocco Di Girolamo, Carolina Cané, Angela Di Somma, Angela Duilio, Antonello Merlino, Delia Picone

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Rosanna LucignanoDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Ilaria StanzioneDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Giarita FerraroDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Rocco Di GirolamoDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Carolina CanéDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Angela Di SommaDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Angela DuilioDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Antonello MerlinoDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
Delia PiconeDepartment of Chemical Sciences, University of Naples Federico II, Naples, Italy.
University of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For their easy and high-yield recombinant production, their high stability in a wide range of physico-chemical conditions and their characteristic hollow structure, ferritins (Fts) are considered useful scaffolds to encapsulate bioactive molecules. Notably, for the absence of immunogenicity and the selective interaction with tumor cells, the nanocages constituted by the heavy chain of the human variant of ferritin (hHFt) are optimal candidates for the delivery of anti-cancer drugs. hHFt nanocages can be disassembled and reassembled

Indexed as

disassembly/reassembly nanocage protocolsdrug encapsulationferritin nanocageshuman ferritin nanocarriersreversible ferritin disassembly

Identifiers

PMID36714262
PMCPMC9880187
OpenAlexW4316041207

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.