ArticleFrontiers in medicine2022
Peripapillary and macular microvasculature features of non-arteritic anterior ischemic optic neuropathy.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Semaglutide-Induced Nonarteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.Journal of clinical pharmacology · 2026Pooled it
- Development of a predictive model for visual outcomes and risk factors of bilateral involvement for non-arteritic anterior ischemic optic neuropathy (NAION) in Chinese patients.Eye and vision (London, England) · 2026Article
- Baseline retinal nerve fiber layer thickness as a predictive biomarker for endoscopic optic canal decompression in NAION: towards a precision medicine approach.Journal of translational medicine · 2026Article
- Adaptive Optics RTX1 Imaging for Early Detection of Retinal Vascular Remodeling in Hypertensive Retinopathy: A Review.Journal of clinical medicine · 2026Review
- Comparison of optic nerve head and macular perfusion changes before and after the development of COVID-19.BMC ophthalmology · 2026Article
- In Vivo Macro-Micro Neurovascular Mapping and Visual Field Correspondence in Non-Arteritic Anterior Ischemic Optic Neuropathy.Ophthalmology and therapy · 2026Article
- Longitudinal assessment of macular structure-function and vasculature-function correlations across different stages of nonarteritic anterior ischemic optic neuropathy.Quantitative imaging in medicine and surgery · 2026Article
- The unexpected sight: improvement of visual function following intracortical microstimulation of the human occipital cortex.Brain communications · 2026Article
- Clues to prognosis in anterior ischemic optic neuropathy: an optical coherence tomography angiography study.International journal of ophthalmology · 2026Article
- Article
- Optic disc characteristics evaluated with swept source optical coherence tomography angiography (SS-OCTA) in nonarteritic anterior ischemic optic neuropathy (NAION): a cross-sectional study.BMC ophthalmology · 2025Article
- Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy.International journal of ophthalmology · 2025Article
- Article
- Peripapillary Microvascular and Structural Parameters in Atrophic Nonarteritic Anterior Ischemic Optic Neuropathy, Unaffected Fellow Eyes and Controls in an Indian Population.Neuro-ophthalmology (Aeolus Press) · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Purpose: The hallmark of non-arteritic anterior ischemic optic neuropathy (NAION) is vascular compromise to the anterior optic nerve and thinning of the retinal nerve fiber layer (RNFL) and secondary degeneration of the retinal ganglion cell body or thinning of the ganglion cell complex (GCC). This study investigates optical coherence tomography (OCT) and OCT Angiography (OCTA) changes in chronic NAION and identifies imaging biomarkers that best predict disease. Methods: We performed a retrospective case-control study of 24 chronic NAION eyes (18 patients) and 70 control eyes (45 patients) to compare both whole-eye and regional OCT, OCTA, static perimetry measurements. OCT measurements were quantified automatically using commercial software, and OCTA was analyzed using custom MATLAB script with large vessel removal to measure 154 total parameters per eye. Results: We confirmed that static perimetry mean deviation (MD) was significantly worse in chronic NAION (-13.53 ± 2.36) than control (-0.47 ± 0.72; Conclusion: Ischemic insult to the optic disk is more severe likely from primary degeneration of the affected peripapillary region while macula is affected by secondary retrograde degeneration and loss of retinal ganglion cells. In addition to OCT measurements, peripapillary and macular vascular parameters such as VAD and flux are good predictors of optic nerve and retinal changes in NAION.
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Registered trials
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