Evidence map›Paper›PMID 36714130›Full record

ArticleFrontiers in medicine2022

The practice of genomic medicine: A delineation of the process and its governing principles.

Julia Handra, Adrienne Elbert, Nour Gazzaz, Ashley Moller-Hansen, Stephanie Hyunh, Hyun Kyung Lee, Pierre Boerkoel, Emily Alderman, Erin Anderson, Lorne Clarke and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Egypt Genome: Towards an African new genomic era.Journal of advanced research · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Julia HandraDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Adrienne ElbertDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Nour GazzazDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Ashley Moller-HansenDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Stephanie HyunhDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Hyun Kyung LeeDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Pierre BoerkoelDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Emily AldermanDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Erin AndersonDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Lorne ClarkeDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Sara HamiltonDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Ronnalea HammanProvincial Medical Genetics Program, British Columbia Women's Hospital and Health Centre, Vancouver, BC, Canada.
Shevaun HughesClinical Research Informatics, Provincial Health Services Authority, Vancouver, BC, Canada.
Simon IpProcess & Systems Improvement, Provincial Health Services Authority, Vancouver, BC, Canada.
Sylvie LangloisDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Mary LeeProvincial Medical Genetics Program, British Columbia Women's Hospital and Health Centre, Vancouver, BC, Canada.
Laura LiBreakthrough Genomics, Irvine, CA, United States.
Frannie MackenzieWomen's Health Research Institute, British Columbia Women's Hospital and Health Centre, Vancouver, BC, Canada.
Millan S PatelDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Leah M PrenticeProvincial Medical Genetics Program, British Columbia Women's Hospital and Health Centre, Vancouver, BC, Canada.
Karan SanghaDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Laura SatoProcess & Systems Improvement, Provincial Health Services Authority, Vancouver, BC, Canada.
Kimberly SeathDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Margaret SeppeltProcess & Systems Improvement, Provincial Health Services Authority, Vancouver, BC, Canada.
Anne SwenertonDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Lynn WarnockProvincial Medical Genetics Program, British Columbia Women's Hospital and Health Centre, Vancouver, BC, Canada.
Jessica L ZamboninDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Cornelius F BoerkoelDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Hui-Lin ChinDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Linlea ArmstrongDepartment of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic medicine, an emerging medical discipline, applies the principles of evolution, developmental biology, functional genomics, and structural genomics within clinical care. Enabling widespread adoption and integration of genomic medicine into clinical practice is key to achieving precision medicine. We delineate a biological framework defining diagnostic utility of genomic testing and map the process of genomic medicine to inform integration into clinical practice. This process leverages collaboration and collective cognition of patients, principal care providers, clinical genomic specialists, laboratory geneticists, and payers. We detail considerations for referral, triage, patient intake, phenotyping, testing eligibility, variant analysis and interpretation, counseling, and management within the utilitarian limitations of health care systems. To reduce barriers for clinician engagement in genomic medicine, we provide several decision-making frameworks and tools and describe the implementation of the proposed workflow in a prototyped electronic platform that facilitates genomic care. Finally, we discuss a vision for the future of genomic medicine and comment on areas for continued efforts.

Indexed as

distributed cognitiongenomic medicineintegrated careprecision medicineworkflow optimization

Identifiers

PMID36714130
PMCPMC9877428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.