Evidence map›Paper›PMID 36714027›Full record

ReviewBioMed research international2023

Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia?

Ming Lu, Jian Liu, Xikun Wu, Zhiqing Zhang

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioMed research international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 7 pooled it
42.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 7 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
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  8. Trial
  9. Ciprofol-Esketamine Versus Ciprofol-Remifentanil in Hysteroscopic Endometrial Polypectomy: A Randomized Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Trial
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  12. Comparison of Ciprofol-Nalbuphine and Propofol-Nalbuphine Sedation During Painless Gastrointestinal Endoscopy: A Randomized Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Trial
  13. Comparison of the Safety and Efficacy of CiprofolCurrent medicinal chemistry · 2026
    Trial
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ming LuDepartment of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050000, China.ORCID https://orcid.org/0000-0003-3381-7191
Jian LiuDepartment of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050000, China.
Xikun WuDepartment of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050000, China.ORCID https://orcid.org/0000-0002-8986-4600
Zhiqing ZhangDepartment of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050000, China.ORCID https://orcid.org/0000-0002-9306-3267
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ciprofol is a novel compound that was independently developed in China. According to the Chinese product instructions approved by the China National Medical Products Administration and the information of official website, indications for ciprofol include sedation and anesthesia during the surgical/procedure of nontracheal intubation, induction and maintenance of general anesthesia, and sedation during intensive care. Ciprofol is a short-acting intravenous sedative based on the structural modification of propofol. Ciprofol has high efficacy, good selectivity, and fewer adverse reactions, indicating good clinical application potential. A series of clinical studies have been conducted to evaluate the sedative effect of ciprofol in various procedures and settings, including gastroscopy and colonoscopy, fiber-optic bronchoscopy, general anesthesia in elective surgeries, and mechanical ventilation in intensive care units. This review summarizes the chemical structure, pharmacodynamics, and pharmacokinetic properties of ciprofol. We also assessed the efficacy and safety of ciprofol by synthesizing the relevant clinical trial data.

Indexed as

PropofolAnesthesia, GeneralAnesthesia, IntravenousAnesthetics, IntravenousClinical Trials as TopicCritical CareHumansHypnotics and SedativesAnesthetics, IntravenousHypnotics and SedativesPropofol

Identifiers

PMID36714027
PMCPMC9879693
OpenAlexW4317498770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.