Evidence map›Paper›PMID 36713810›Full record

ArticleAlgorithms2022

Designing Reinforcement Learning Algorithms for Digital Interventions: Pre-Implementation Guidelines.

Anna L Trella, Kelly W Zhang, Inbal Nahum-Shani, Vivek Shetty, Finale Doshi-Velez, Susan A Murphy

Abstract read
In one paragraph

Article in Algorithms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Offline Reinforcement Learning for Adaptive Support in AI-Assisted Decision-Making.ACM transactions on computer-human interaction : a publication of the Association for Computing Machinery · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Replicable Bandits for Digital Health Interventions.Statistical science : a review journal of the Institute of Mathematical Statistics · 2025
    Article
  10. Article
  11. Reinforcement Learning on Dyads to Enhance Medication Adherence.Artificial intelligence in medicine. Conference on Artificial Intelligence in Medicine (2005- ) · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Contextual Bandits with Budgeted Information Reveal.Proceedings of machine learning research · 2024
    Article
  16. Reinforcement Learning Interventions on Boundedly Rational Human Agents in Frictionful Tasks.Proceedings of the ... International Joint Conference on Autonomous Agents and Multiagent Systems : AAMAS. International Joint Conference on Autonomous Agents and Multiagent Systems · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna L TrellaSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02420, USA.
Kelly W ZhangSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02420, USA.
Inbal Nahum-ShaniInstitute for Social Research, University of Michigan, Ann Arbor, MI 48109, USA.
Vivek ShettySchools of Dentistry & Engineering, University of California, Los Angeles, CA 90095, USA.
Finale Doshi-VelezSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02420, USA.
Susan A MurphySchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02420, USA.

Funding

Pilot and Mentoring CoreP50DA054039 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LINDA M COLLINS, SUSAN A MURPHY · 2021 to 2026
$18.2M
TR&D3 - Rapid Translation of AI-powered Temporally Precise mHealth Interventions via Efficient and Embeddable Trustworthy Biomarker ImplementationsP41EB028242 · NIBIB · UNIVERSITY OF MEMPHIS · PI Santosh Kumar · 2020 to 2026
$9.5M
Novel Methods for Intensive Longitudinal Data in SMART Studies of Drug Abuse and HIVR01DA039901 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALMIRALL, DANIEL, NAHUM-SHANI, INBAL BILLIE · 2015 to 2024
$5.4M
Personalized Digital Behavior Change Interventions to Promote Oral HealthUH3DE028723 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VIVEK SHETTY · 2022 to 2026
$3.8M
Data-driven subtyping in major depressive disorderR01MH123804 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI PERLIS, ROY H. · 2021 to 2024
$3.1M
Novel use of mHealth data to identify states of vulnerability and receptivity to JITAIs SupplementU01CA229437 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NAHUM-SHANI, INBAL BILLIE, WETTER, DAVID W · 2018 to 2022
$2.8M
Personalized Digital Behavior Change Interventions to Promote Oral HealthUG3DE028723 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHETTY, VIVEK · 2019 to 2019
$460k
NCI NIH HHS U01 CA229437NIBIB NIH HHS P41 EB028242NIDA NIH HHS P50 DA054039NIDA NIH HHS R01 DA039901NIDCR NIH HHS UG3 DE028723NIDCR NIH HHS UH3 DE028723NIMH NIH HHS R01 MH123804
6 · The paper itself

Abstract

Online reinforcement learning (RL) algorithms are increasingly used to personalize digital interventions in the fields of mobile health and online education. Common challenges in designing and testing an RL algorithm in these settings include ensuring the RL algorithm can learn and run stably under real-time constraints, and accounting for the complexity of the environment, e.g., a lack of accurate mechanistic models for the user dynamics. To guide how one can tackle these challenges, we extend the PCS (predictability, computability, stability) framework, a data science framework that incorporates best practices from machine learning and statistics in supervised learning to the design of RL algorithms for the digital interventions setting. Furthermore, we provide guidelines on how to design simulation environments, a crucial tool for evaluating RL candidate algorithms using the PCS framework. We show how we used the PCS framework to design an RL algorithm for Oralytics, a mobile health study aiming to improve users' tooth-brushing behaviors through the personalized delivery of intervention messages. Oralytics will go into the field in late 2022.

Indexed as

algorithm designalgorithm evaluationmobile healthonline learningreinforcement learning (RL)

Identifiers

PMID36713810
PMCPMC9881427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.