ArticleFrontiers in cellular neuroscience2022
Elucidating afferent-driven presynaptic inhibition of primary afferent input to spinal laminae I and X.
Article in Frontiers in cellular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Optogenetic Approach for Investigating Descending Control of Nociception in Ex Vivo Spinal Cord Preparation.Bio-protocol · 2025Article
- Activation of TRPA1 and TRPM3 triggers CaThe Journal of physiology · 2025Article
- Approach for Electrophysiological Studies of Spinal Lamina X Neurons.Bio-protocol · 2024Article
- Nerve Preparation and Recordings for Pharmacological Tests of Sensory and Nociceptive Fiber Conduction Ex Vivo.Bio-protocol · 2024Article
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8 authors.
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Abstract
Although spinal processing of sensory information greatly relies on afferent-driven (AD) presynaptic inhibition (PI), our knowledge about how it shapes peripheral input to different types of nociceptive neurons remains insufficient. Here we examined the AD-PI of primary afferent input to spinal neurons in the marginal layer, lamina I, and the layer surrounding the central canal, lamina X; two nociceptive-processing regions with similar patterns of direct supply by Aδ- and C-afferents. Unmyelinated C-fibers were selectively activated by electrical stimuli of negative polarity that induced an anodal block of myelinated Aβ/δ-fibers. Combining this approach with the patch-clamp recording in an
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