Evidence map›Paper›PMID 36713458›Full record

ArticleFrontiers in immunology2022

MRI/PET multimodal imaging of the innate immune response in skeletal muscle and draining lymph node post vaccination in rats.

Saaussan Madi, Fang Xie, Kamyar Farhangi, Chih-Yang Hsu, Shih-Hsun Cheng, Tolulope Aweda, Bhasker Radaram, Stephanie Slania, Tammy Lambert, Mary Rambo and 14 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 2 institutions in 2 countries.

Saaussan MadiBioimaging, GSK, Collegeville, PA, United States.
Fang XieBioimaging, GSK, Collegeville, PA, United States.
Kamyar FarhangiBioimaging, GSK, Collegeville, PA, United States.
Chih-Yang HsuBioimaging, GSK, Collegeville, PA, United States.
Shih-Hsun ChengBioimaging, GSK, Collegeville, PA, United States.
Tolulope AwedaBioimaging, GSK, Collegeville, PA, United States.
Bhasker RadaramBioimaging, GSK, Collegeville, PA, United States.
Stephanie SlaniaBioimaging, GSK, Collegeville, PA, United States.
Tammy LambertNon Clinical Safety, GSK, Collegeville, PA, United States.
Mary RamboBioimaging, GSK, Collegeville, PA, United States.
Tina SkedzielewskiBioimaging, GSK, Collegeville, PA, United States.
Austin ColeResearch Statistics, GSK, Collegeville, PA, United States.
Valeriia SherinaResearch Statistics, GSK, Collegeville, PA, United States.
Shannon McKearnanResearch Statistics, GSK, Collegeville, PA, United States.
Hoang TranResearch Statistics, GSK, Collegeville, PA, United States.
Hasan AlsaidBioimaging, GSK, Collegeville, PA, United States.
Minh DoanBioimaging, GSK, Collegeville, PA, United States.
Alan H StokesNon Clinical Safety, GSK, Collegeville, PA, United States.
Derek T O'HaganVaccines Research & Development, GSK, Rockville, MD, United States.
Giulietta MaruggiVaccines Research & Development, GSK, Rockville, MD, United States.
Sylvie BertholetVaccines Research & Development, GSK, Rockville, MD, United States.
Stéphane T TemmermanVaccines Research & Development, GSK, Rixensart, Belgium.
Russell JohnsonVaccines Research & Development, GSK, Rockville, MD, United States.
Beat M JuckerClinical Imaging, GSK, Collegeville, PA, United States.
GlaxoSmithKline (United States) · USGlaxoSmithKline (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goal of this study was to utilize a multimodal magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging approach to assess the local innate immune response in skeletal muscle and draining lymph node following vaccination in rats using two different vaccine platforms (AS01 adjuvanted protein and lipid nanoparticle (LNP) encapsulated Self-Amplifying mRNA (SAM)). MRI and

Indexed as

Cytomegalovirus InfectionsFluorodeoxyglucose F18AnimalsCytomegalovirusImmunity, InnateLymph NodesMagnetic Resonance ImagingMultimodal ImagingMuscle, SkeletalPositron-Emission TomographyRatsVaccinationFluorodeoxyglucose F18AS01innate immune activationlipid nanoparticlemagnetic resonance imagingpositron emission tomographyself-amplifying mRNA

Identifiers

PMID36713458
PMCPMC9874296
OpenAlexW4315649540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.