ArticlePNAS nexus2023
Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026Review
- Inhibition of Toxoplasma gondii proliferation by dimethyl itaconate: Evidence from in vitro and in vivo studies.PLoS neglected tropical diseases · 2026Article
- ACOD1 deficiency promotes DDX1 methylation-mediated mitochondrial dysfunction and dermal papilla cell senescence in androgenetic alopecia.BMC medicine · 2026Article
- Pyroptosis in Alopecia Areata: Synthesizing Emerging Hypotheses and Charting a Path to New Therapies.Biomedicines · 2025Review
- Hyperglycemia-Suppressed Acod1 Expression Contributes to Innate Immune Deficiency in Pseudomonas aeruginosa Keratitis.Investigative ophthalmology & visual science · 2025Article
- Discovery of Orally Available Prodrugs of Itaconate and Derivatives.Journal of medicinal chemistry · 2025Article
- Enhanced Drug Skin Permeation by Azone-Mimicking Ionic Liquids: Effects of Fatty Acids Forming Ionic Liquids.Pharmaceutics · 2024Article
- JAK inhibitor selectivity: new opportunities, better drugs?Nature reviews. Rheumatology · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
30 authors at 5 institutions in 3 countries.
Jerry TsaiDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0003-3480-2952
Sadakatali GoriJohns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0003-0840-829X
Jesse AltJohns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0001-5440-7891
Sandhya TiwariIn Vitro Biology, Sun Pharma Advanced Research Company, Savli, 391770, India.
Jitesh IyerIn Vitro Biology, Sun Pharma Advanced Research Company, Savli, 391770, India.
Rashmi TalwarIn Vitro Biology, Sun Pharma Advanced Research Company, Savli, 391770, India.
Denish HinsuPreclinical Pharmacology, Sun Pharma Advanced Research Company, Savli, 391770, India.
Kailash AhirwarDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research Ahmedabad, Gandhinagar 382355, India.
Swayam MohantyPreclinical Pharmacology, Sun Pharma Advanced Research Company, Savli, 391770, India.
Chintan KhuntPreclinical Pharmacology, Sun Pharma Advanced Research Company, Savli, 391770, India.
Brijesh SutariyaDepartment of Internal Medicine, Division of Hematology/Oncology, University of Iowa, Iowa City, IA 52242, USA.ORCID https://orcid.org/0000-0001-8602-0966
Kaushal JaniPreclinical Pharmacology, Sun Pharma Advanced Research Company, Savli, 391770, India.
Venkatesha VenkatasubbaiahPreclinical Pharmacology, Sun Pharma Advanced Research Company, Savli, 391770, India.
Ashok PatelDrug Metabolism and Pharmacokinetics, Sun Pharma Advanced Research Company, Savli, 391770, India.
Jasmin MeghaparaDrug Metabolism and Pharmacokinetics, Sun Pharma Advanced Research Company, Savli, 391770, India.
Kaushal JoshiDrug Metabolism and Pharmacokinetics, Sun Pharma Advanced Research Company, Savli, 391770, India.
Rajanikanta SahuDrug Metabolism and Pharmacokinetics, Sun Pharma Advanced Research Company, Savli, 391770, India.
Vijay RanaDrug Metabolism and Pharmacokinetics, Sun Pharma Advanced Research Company, Savli, 391770, India.
Prashant NigadeDrug Metabolism and Pharmacokinetics, Sun Pharma Advanced Research Company, Savli, 391770, India.
Ravi S TalluriClinical Pharmacology, Sun Pharma Advanced Research Company, Mahakali, Mumbai 400093, India.
Kadiyala V S N MurtyMedicinal Chemistry, Sun Pharma Advanced Research Company, Savli 391770, India.
Kiritkumar JoshiMedicinal Chemistry, Sun Pharma Advanced Research Company, Savli 391770, India.
Vikram RamanathanTranslational Development, Sun Pharma Advanced Research Company, Savli 391770, India.
Ang LiDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0002-3421-5726
Nasif IslamDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0002-6793-2190
Ivan SnajdrInstitute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Prague 166 10, Czech Republic.ORCID https://orcid.org/0000-0002-0831-4034
Pavel MajerInstitute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Prague 166 10, Czech Republic.
Rana RaisJohns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0003-4059-2453
Barbara S SlusherJohns Hopkins Drug Discovery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0001-9814-4157
Luis A GarzaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID https://orcid.org/0000-0002-6547-9695
Sun Pharma Advanced Research (India) · INJohns Hopkins University · USCzech Academy of Sciences · CZNational Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad · INUniversity of Iowa · US
Funding
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7MMechanism and clinical pilot tst of volar fibroblast to create ectopic volar skinR01AR064297 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2013 to 2017
$1.8MTowards the clinical testing of dsRNA to promote wound induced hair neogenesisR01AR068280 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2016 to 2018
$718kNCATS NIH HHS UL1 TR003098NIAMS NIH HHS R01 AR064297NIAMS NIH HHS R01 AR068280
Abstract
Alopecia areata is a chronic hair loss disorder that involves autoimmune disruption of hair follicles by CD8
Indexed as
alopecia areataanagencytokinecytotoxicitydouble-stranded RNAhair cyclehair growthimmunosuppressioninflammationinterferoninterleukinitaconatekeratinocytepharmacokineticspolyinosinic–polycytidylic acidprodrugstabilitytelogentopical
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.