Evidence map›Paper›PMID 36712851›Full record

ArticleFrontiers in genetics2022

Genome-wide association study in a rat model of temperament identifies multiple loci for exploratory locomotion and anxiety-like traits.

Apurva S Chitre, Elaine K Hebda-Bauer, Peter Blandino, Hannah Bimschleger, Khai-Minh Nguyen, Pamela Maras, Fei Li, A Bilge Ozel, Yanchao Pan, Oksana Polesskaya and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

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  16. The neurobiology of stress: Vulnerability, resilience, and major depression.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Apurva S ChitreDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Elaine K Hebda-BauerMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Peter BlandinoMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Hannah BimschlegerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Khai-Minh NguyenDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Pamela MarasMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Fei LiMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
A Bilge OzelDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Yanchao PanDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Oksana PolesskayaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Riyan ChengDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
Shelly B FlagelMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Stanley J WatsonMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Jun LiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Huda AkilMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, United States.
University of Michigan · USUniversity of California San Diego · US

Funding

Investigating the role of Bmp4 in glial subtype specification and temperamentU01DA043098 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUDA AKIL, Jun Li · 2017 to 2026
$6.9M
NIDA NIH HHS U01 DA043098
6 · The paper itself

Abstract

Common genetic factors likely contribute to multiple psychiatric diseases including mood and substance use disorders. Certain stable, heritable traits reflecting temperament, termed externalizing or internalizing, play a large role in modulating vulnerability to these disorders. To model these heritable tendencies, we selectively bred rats for high and low exploration in a novel environment [bred High Responders (bHR) vs. Low Responders (bLR)]. To identify genes underlying the response to selection, we phenotyped and genotyped 538 rats from an F

Indexed as

anxiety like behaviorsbehaviorexploratory locomotiongenome-wide association studyGWASrat model

Identifiers

PMID36712851
PMCPMC9873817
OpenAlexW4315487401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.