ArticlePNAS nexus2022
Declaration of common standards for the preregistration of animal research-speeding up the scientific progress.
Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Building a synthesis-ready research ecosystem: fostering collaboration and open science to accelerate biomedical translation.BMC medical research methodology · 2025Pooled it
- Good Practice Guideline for Preclinical Alcohol Research: The STRINGENCY Framework.Current topics in behavioral neurosciences · 2025Guideline
- Preregistration of Preclinical Animal Studies as a Tool for Refinement: A Feasibility Study Comparing the German Animal Study Registry and Preclinicaltrials.eu.Animals : an open access journal from MDPI · 2026Article
- A survey of researchers' attitudes to preregistration in animal research reveals multiple perceived barriers to adoption.PLoS biology · 2026Article
- A call for preregistration of in vitro research : Pregistration as a tool to improve reproducibility and transparency.EMBO reports · 2026Article
- Improving research transparency with individualized report cards: A feasibility study in clinical trials at a large university medical center.BMC medical research methodology · 2025Article
- Strengthening translational preclinical research through confirmatory multi-laboratory studies.Frontiers in medicine · 2025Article
- A facility for laboratory mice with a natural microbiome at Charité - Universitätsmedizin Berlin.Lab animal · 2024Article
- 3R centres contributions to change animal experimentation : A field report from Charité 3EMBO reports · 2024Article
- A call to implement preclinical study registration in animal ethics review.PLoS biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preregistration of studies is a recognized tool in clinical research to improve the quality and reporting of all gained results. In preclinical research, preregistration could boost the translation of published results into clinical breakthroughs. When studies rely on animal testing or form the basis of clinical trials, maximizing the validity and reliability of research outcomes becomes in addition an ethical obligation. Nevertheless, the implementation of preregistration in animal research is still slow. However, research institutions, funders, and publishers start valuing preregistration, and thereby level the way for its broader acceptance in the future. A total of 3 public registries, the
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.